Bone marrow cells, both myeloid and erythroid, are among the few that exhibit active multiplication in the adult. The metabolism of these cells is consequently of interest in connection with studies of normal and abnormal growth. It is the purpose of this paper to review certain pertinent data on bone marrow metabolism and to add new data permitting a consideration of bone marrow metabolism in ...

Introduction:Omeprazole (OP) is one the proton pump inhibitor (PPI) agents, and available over the counter in generic formulations. Epidemiological investigations have been confirmed a relationship between long term use of PPI agents and bone metabolism. Bone scintigraphy is commonly used for analysing the bone metabolism in clinical practice. This study was conducted to assess...

Welcome to the inaugural special issue of PPAR Research: PPARs and Bone Metabolism. In addition to the key roles PPARs play in numerous processes including glucose and fat metabolism, inflammation, cancer, and central nervous system maintenance, a new role for PPAR-γ has recently emerged: the maintenance of bone homeostasis during aging and disease. In this premier issue we have assembled what ...

Diabetes mellitus has been demonstrated to be closely associated with osteoporosis. Accordingly, hypoglycemic therapy is considered effective in treating metabolic bone disease. Recently, the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors, a new type of antidiabetic drug, on bone metabolism have been widely studied. This review mainly describes the effects of DPP-4 inhibitors on bone meta...

BACKGROUND Osteocalcin (OC) is produced by osteoblasts during bone formation, and circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is excreted into urine by glomerular filtration and can be found in urine as midmolecule fragments. METHODS We developed and evaluated three immunoassays (U-MidOC, U-LongOC, and U-TotalOC) for the detection of various mole...

Several authors have confirmed that 27 to 38% of AIS patients had osteopenia. But few studies have assessed bone metabolism in AIS. This study assessed bone mineral density and bone metabolism in AIS patients using the bone metabolism markers, BAP and TRAP5b. The subjects were 49 consecutive adolescent AIS patients seen at our institutes between March 2012 and September 2013. Sixty-five percent...

Background: Evidence suggests that vitamin D status in adults is positively associated with calcium absorption fraction and inversely associated with serum PTH. The objective of this study was to evaluate the relationships among vitamin D status, PTH, and calcium absorption in midpubertal boys and girls. Methods: Calcium absorption was measured by using a stable isotope method in 93 young adole...

The aim of this study was to evaluate the changes in bone metabolism in breastfeeding women (BF). We selected 30 primiparous women and compared them to 31 nulliparous women. We assessed bone mineral density (BMD) in the lumbar spine (LS), femoral neck (FN) and trochanter (TROC), biochemical parameters of bone turnover and hormone and cytokine levels at the puerperium, 6 months and 12 months aft...

range from detailed reports of animal experiments and of metabolic balance studies in man to a very stimulating and speculative essay by D. J. Ingle concerning Selye's adaptation hypothesis. The papers in this symposium bring out very clearly that although intensive studies have been carried out in certain spheres concerning the effects of aging, there are many other areas which are virtually u...