The purpose of this study was to investigate various serum markers of bone turnover in non-small cell lung cancer patients (NSCLC) in the presence or absence of bone metastasis. Our retrospective study included 79 newly diagnosed NSCLC patients. Group A included 51 patients with bone metastasis and group B included 28 patients that never developed bone metastasis. The measurement of bone format...

BACKGROUND The present study measured longitudinal changes in bone turnover markers in elderly patients with vertebral fracture and investigated the relationship among bone turnover markers, duration of bed rest and bone mineral density (BMD). METHODS Criteria for patient selection were 50 years in age and older, and presence of VF. Serum bone-specific alkaline phosphatase (BAP) was measured ...

Thyroid hormones affect bone metabolism by altering normal bone remodeling processes. This study involved assessment of biochemical markers of bone turnover in 94 patients with thyroid dysfunction. Clear hypocalcaemia was observed in hypothyroidism while in hyperthyroid patients there was frank hypercalcaemia. In hyperthyroidism there is increased activity of osteoclast which leads to increased...

Diabetes and osteoporosis are both frequent disorders. By chance they may thus occur together. However, evidence suggests that osteoporosis defined by bone scans (DXA) occurs more frequent than expected in type 1 diabetes (T1D) and less frequent than expected in T2D (1). The latter may be explained by differences in body size – T2D patients being more obese than the general population and bone ...

OBJECTIVE Accumulating evidence suggests that statins might positively affect bone metabolism. In the present study, we compared the effect of rosuvastatin with that of ezetimibe on bone turnover markers in patients with type 2 diabetes mellitus as well as hypercholesterolemia. DESIGN AND METHODS A total of 36 Japanese patients were enrolled in this open-label study and randomized to either r...

Objective: To examine the associations between bone turnover markers (BTMs) and mineral density (BMD) in older adults aged 60–85 years. Methods: A total of 1124 men (mean age, 69.1 years) 1203 women 70.7 from National Health Nutrition Examination Survey 1999–2002 were included this cross-sectional analysis. Independent variables serum bone-specific alkaline phosphatase (sBAP) urinary N-telopept...

This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I. These include carboxy- and aminoterminal telopeptide, carboxy- and aminoterminal propeptide of procollagen type I, hydroxyproline, hydroxylysine, pyridinoline and deoxypyridinoline. Their measurement allows evaluating the structural an...