AIM It is known that botulinum neurotoxin type A (BoNTA) improves some kinds of cancer (e.g. prostate) and that synaptic vesicle glycoprotein 2 (SV2) is the molecular target of this neurotoxin. Besides having potential therapeutic value, this glycoprotein has recently been proposed as a molecular marker for several types of cancer. Although the mechanisms of cancer development and the improveme...

In this article we follow-up on previous works pertaining to separate models of sexual offending as these relate to assessment and treatment: the Good Lives Model of offender rehabilitation (Ward & Gannon, 2006; Ward & Stewart, 2003), the Self-Regulation Model of the sexual offence process (Ward & Hudson, 1998), and our reconstruction (Ward, Melser, & Yates, 2007) of the Risk/Need/Responsivity ...

A N indication that seasonal variation may influence the incidence of esophagogastric ulcers in swine has been reported by Kowalczyk et al. (1960), Kowalczyk and Muggenburg (1963) and Curtin et al. (1963). More ulcers and deaths due to ulcer were observed during the spring and winter months. The possibility that the temperature changes which occurred during this time were placing an increased s...

BACKGROUND Botulinum neurotoxin A (BoNT/A), mainly represented by subtype A1, is the most toxic substance known. It causes naturally-occurring food poisoning, and is among the biological agents at the highest risk of being weaponized. Several antibodies neutralizing BoNT/A by targeting its heavy chain (BoNT/A-H) have been isolated in the past. For the first time however, an IgG (4LCA) recently ...

Our paper, ‘Human Geography without Scale’ (Marston et al. 2005), is developed in two parts: a critique that is immanent to scale, where we show that, even on the grounds of contemporary spatial theory, the concept is deficient; and a critique that is extrinsic to those grounds, where we make a contribution to an alternative ontology that does not rely on the transcendental abstraction of scale...

M uch of the focus of programming evaluation research has been on the impact of recidivism rates for the high-risk offender. With limited funding and resources, it is necessary to direct services to the group that can potentially demonstrate the largest percentage decline in recidivism. Although this is certainly appropriate, there is a need to identify the types and amounts of treatment and pr...

This report investigates the effect of the negative enantiomer of 1-hydroxy-3-aminopyrrolidone-2 (HA-966) on behavioral and biochemical changes elicited by pharmacological or experimental paradigms which activate mesocorticolimbic dopaminergic neurotransmission. Several paradigms were used, including cocaine sensitization and two stressors: restraint for 30 min and an aversive conditioning mode...

Citation for published version (APA): Cairns, B. E. (2016). The role of glutamate and peripheral N-Methyl-D-Aspartate (NMDA) receptors in masticatory muscle pain mechanisms. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recogn...

This paper examines our current understanding of the phenomena of emergence delirium, which can occur following general anesthesia. Much research has been conducted to elucidate the causative factors of this condition, with findings ranging from anxiety to volatile agents and the neurodevelopment of the brain (Aono, Ueda, & Mamiya, 1997; Kain et al., 2004; McLott, Jurecic, Hemphill, & Dunn, 201...