We constructed an oral live vaccine based on the attenuated aroA mutant Salmonella enterica serovar Typhimurium strain SL3261 expressing outer membrane proteins F and I (OprF-OprI) from Pseudomonas aeruginosa and investigated it in a mouse model. Strains with in vivo inducible protein expression with the PpacC promoter showed good infection rates and immunogenicity but failed to engender detect...

Based on the local incidence and severity of motor vehicle occupant injuries, the authors' community and hospital injury prevention partnership identified child passenger safety for 4-to-8-year-old children as a priority. They designed a booster seat promotion campaign using an integrated social cognition model of health behavior. A series of focus groups were held with low-income African Ameri...

OBJECTIVE To evaluate the immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type b conjugate vaccine (PRP-T) in Brazilian infants. MATERIAL AND METHODS A prospective and open clinical study, in which 110 infants were immunized with a three-dose primary vaccination regime at two, four and six months of age and with a single booster vaccination. Blood samp...

Immunization with acellular pertussis vaccine (aP) induces higher specific antibody levels and fewer adverse reactions than does immunization with the whole-cell vaccine (wP). However, antibody levels in infants induced by both types of pertussis vaccines wane already after 1 year. Therefore, long-term T-cell responses upon vaccination might play a role in protection against pertussis. In a cro...

OBJECTIVES To examine factors associated with compliance and with perceived readiness for the new Washington State booster seat law, and to identify perceived barriers to compliance among licensed childcare centers. DESIGN/METHODS Surveys were mailed to a random sample of 550 licensed childcare centers in Washington State, approximately nine months before the law was to go into effect. RESU...

We evaluated the reactogenicity and immunogenicity of a booster dose of diphtheria-tetanus vaccine administered at the age of school-entry, comparing a low-dose vaccine (dT) to the standard paediatric dose (DT). Participants were randomly assigned to receive one of the two vaccines; the study was evaluator-blinded. The frequency of side-reactions was similar when comparing the two groups, excep...

An experimental study was conducted to determine the proximity aeroheating characteristics for a two-stage-to-orbit concept in close proximity in the NASA Langley 20-Inch Mach 6 Air Tunnel. A new hybrid discrete thin-film resistance gauge technique was evaluated in this study and used to measure experimental interference heating levels between the booster and the orbiter at a constant freestrea...

BACKGROUND Vaccination with the hepatitis B surface antigen (HBsAg) induces protective levels of antibody (anti-HBs = 10 IU/L) in majority of vaccinees. It has been shown that the levels of anti-HBs antibody do wane after vaccination. The aim of this study was to evaluate the persistence of anti-HBs antibodies in healthy Iranian children at 10 years after primary vaccination and the response to...

A report on the challenges confronting the Fermilab Linac and Booster accelerators is presented. Plans to face those challenges are discussed. Historically, the Linac/Booster system has served only as an injector for the relatively low repetition rate Main Ring synchrotron. With construction of an 8 GeV target station for the 5 Hz MiniBooNE neutrino beam and requirements for rapid multi-batch i...