BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) bromodomain (BRD) has moderate specificity for H3K14ac. Surprisingly, we also find that both BRG1 and hBRM BRDs have DNA-binding activity. We demonstrate that the BRDs associate with DNA through a surface basic patch and th...

1Over the past few years, several approaches to scheduling have been proposed that attempt to reduce tardiness and inventory costs by opportunistically (i.e. dynamically) combining resource-centered perspective to schedule bottleneck resources, and a job-centered perspective to schedule non-bottleneck operations on a job by job basis. Rather than relying on their initial bottleneck analysis, th...

The main reasons for the failure of most chemopreventive agents during clinical trials are poor in vivo bioavailability and dose-limiting side effects. One potential approach to surmount these problems in lung cancer chemoprevention trials could be direct delivery of agents into the pulmonary tissue. In this study, we assessed the efficacy of intranasally delivered bio-response diindolylmethane...

Buffers decouple fluctuations in the material flow. It is common wisdom in industry that a full buffer indicates a downstream bottleneck and an empty buffer indicates an upstream bottleneck. Numerous different bottleneck detection methods use this approach to detect the bottlenecks. However, so far this common wisdom on the shop floor has not yet been verified academically. The authors tested t...

BACKGROUND Pasteurella multocida, Mannheimia haemolytica, Histophilus somni and Trueperella pyogenes are four bacterial agents commonly associated with bovine respiratory disease (BRD). In this study a bacterial multiplex real-time PCR (the RespoCheck PCR) was evaluated for the detection in bronchoalveolar lavage fluid (BALF) of these four bacterial agents. RESULTS The analytical sensitivity ...

We investigated whether environmental support can be used to circumvent the problem state bottleneck in human multitasking. Previously, it was shown that people can only maintain a single chunk of information in their problem state resource, the central part of working memory. Consequently, when the problem state resource was required by multiple tasks concurrently, performance decreased. This ...

Early detection of Alzheimer's Disease (AD) and its prodromal state, Mild Cognitive Impairment (MCI), is crucial for providing suitable treatment preventing the disease from progressing. It can also aid researchers clinicians to identify early biomarkers minister new treatments that have been a subject extensive research. The application deep learning techniques on structural Magnetic Resonance...

BACKGROUND Bovine respiratory disease (BRD) is one of the leading causes of economic losses in the beef and dairy industry. Reliable antemortem tools for diagnosing BRD would improve the efficacy of treatment and reduce costs. Here we examined whether the relatively simple technique of thoracoscopy can support BRD diagnosis under field conditions. We also compared various equipment set-ups in o...

We investigated whether environmental support can be used to circumvent the problem state bottleneck in human multitasking. Previously, it was shown that people can only maintain a single chunk of information in their problem state resource, the central part of working memory. Consequently, when the problem state resource was required by multiple tasks concurrently, performance decreased. This ...