Current research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed study how selected independent variables affect dependent responses. After the initial test, items were as follows; polyvi...

Nanoliposomes are bilayer phospholipid vesicles used to encapsulate and deliver therapeutic agents. The study was aimed investigate the effects of critical variables on nanoliposomes characteristics. Imatinib mesylate-loaded were formulated by two-step emulsification process using a high-speed homogenizer system probe-type ultrasonicator. Box-Behnken design utilized optimize parameters. mean pa...

background contamination of water resources with nitrate is a serious environmental problem in many regions of the world. in addition, this problem has been observed in some regions of iran. as nitrate is threatening for human health and environment, it must be decreased to standard levels in drinking water. objectives the purpose of this research was to model the nitrate removal from water by ...

A Response surface design of experiment has been performed based on the Muschelknautz method of modeling (MM) for 64 test cases using Box-Behnken design to study the effect of seven geometrical cyclone dimensions on the pressure drop and cut-off diameter. It is found that the most significant geometrical parameters are, the vortex finder diameter, the inlet section width and height, and the cyc...

A new method based on accelerated solvent extraction (ASE) combined with response surface methodology (RSM) modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill). The RSM method, based on a three level and three variable Box-Behnken design (BBD), was employed to obtain the optimal combination of extracti...

In this work, a rapid extraction method based on ultrasound-assisted extraction (UAE) of syringin from the bark of Ilex rotunda Thumb using response surface methodology (RSM) is described. The syringin was analyzed and quantified by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time, the three main facto...

Three most commonly used preparative methods, dry-film, reverse phase evaporation and ethanol injection were employed to prepare cationic liposomes composed of DC-Chol and DOPE, respectively. The resulting samples were contrasted through morphology observation, particle size and zeta potential analysis. Sephadex filtration method with high selectivity was developed to determine the encapsulatio...