Israel’s organ-transplantation history dates back to 1964, when the first kidney transplantation from a living related donor was performed. In 1965, the first kidney transplantation from a deceased donor was successfully accomplished. Currently six Israeli medical centers perform kidney, heart, lung, and liver transplantations. The Israel National Transplant Center (INTC) coordinates all donors...

the exact developmental origin of microglia is still under debate. in the present study we investigated which heamatopoietic tissues and which features of the organotypic brain slice culture promoted microglia ramification. the potential of cells derived from embryonic yolk sac, embryonic aorta-gonad-mesonephros and adult blood monocytes was examined. these tissues were co-cultured with brain s...

The US Uniform Determination of Death Act provides two alternatives for determining death-the circulatory criteria and the neurological criteria-yet history and the public's current understanding of death in the US may mean that only brain death criteria can be relied upon without raising public suspicion that the medical profession is sacrificing the well-being of one group of patients (i.e., ...

INTRODUCTION Perhaps one of the greatest achievements in medicine to date, organ transplantation has transformed the lives of thousands – bringing life to those who would surely have died without it. This achievement is dependent upon a generous gift from another person. From one deceased donor up to 55 lives may be saved or improved.1 With progressive advances in the trauma system, emergency p...

The lifesaving processes of organ donation and transplantation in neonatology and pediatrics carry important ethical considerations. The medical community must balance the principles of autonomy, non-maleficence, beneficence, and justice to ensure the best interest of the potential donor and to provide equitable benefit to society. Accordingly, the US Organ Procurement and Transplantation Netwo...

Background: Brain dead patients are the main source of organs for transplants. Brain death causes changes in peripheral organs. We define modifications of gene expression in specific pathways occurring in donor livers and their influence on gene expression profile of livers after transplant. Methods: We compared gene expression profile of both deceased donor livers and transplanted livers to ge...