introduction: the wilson disease is an autosomal recessive disease in which the liver, central nervous system, eyes, blood and other parts of the body involved. timely diagnosis and appropriate treatment of the disease requires awareness of the clinical presentations of this disease in children.methods: this case series study included 62 patients with wilson disease who admitted to children&apo...

Background: Diazinon (Dzn), an Organophosphorus (OP) pesticide, is extensively used in agriculture. Acetylcholinesterase inhibition is linked to OP toxicity, and there are major mental health concerns associated with the use of pesticides. The objective of this study was to assess the depressive behavior in an animal model following their exposure to Dzn and the effect on the Brain-Derived Neur...

When a central nervous system (CNS) lesion is found in patients with chronic lymphocytic leukemia (CLL), the diagnostic possibilities include CNS involvement of CLL, transformation to large B-cell lymphoma (Richter’s syndrome [RS]), or coincidental presence another tumorous non-tumorous disease. RS commonly occurs preexisting CLL other nodal/extra-nodal involvement, but it extremely rare find i...

Diagnostic criteria for neuromyelitis optica (NMO) state that there should be no active disease outside the optic nerves and spinal cord. However, several cases have been described with symptomatic brain involvement. We describe an autopsy case of a patient with NMO and symptomatic involvement of the brain. The histopathology of the brain lesions is typical for NMO, with extensive macrophage in...

Abstract Several clinical studies have reported a double dissociation between abstract and concrete concepts, suggesting that they are processed by at least partly different networks in the brain. However, neuroimaging data seem not line with neuropsychological reports. Using ALE method, we run meta-analysis on 32 brain-activation imaging considered only nouns verbs. Five clusters were associat...

Neurodegenerative diseases are debilitating disorders which compromise motor or cognitive functions and rapidly becoming a global communal disorder with over 46.8 million people suffering dementia worldwide. Aetiological studies have showed that who exposed to agricultural, occupational environmental toxic chemicals can interfere degenerate dopaminergic neurons prone developing neurodegenerativ...

Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a rel...

Intracranial involvement with histiocytosis is usually limited to the hypothalamus and associated with extensive extracranial disease. We report the CT and MR findings in a patient with biopsy-proved histiocytosis presenting as multifocal intracranial involvement without any systemic disease. While extrahypothalamic CNS involvement by histiocytosis is well recognized (1-9], infiltrative brain i...

Background We recently demonstrated that brain natriuretic peptide is expressed in the dorsal root ganglia, and that brain natriuretic peptide is required for normal detection of pruritogens. We further showed that the receptor for brain natriuretic peptide, natriuretic peptide receptor A, is present in the spinal cord, and elimination of these neurons profoundly attenuates scratching to itch-i...

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, airways, lymph nodes, liver, brain, bones. These most commonly occur in organs contact with outside world (lungs, gastrointestinal tract, skin), as well nodes that drain these structures. While involvement can be seen many organs, there no k...