IN mammalian teratology, a malformation consisting of 'overgrowth' of the neural tube has been described by, among others, Patten (1952,1957) and Ariens Kappers (1956, 1957). Sjodin (1957) thought it to be a post-mortem effect and not a true malformation. The present author (1955) demonstrated that a similar malformation could be produced in the rostral part of the brain of chick embryos by ope...

sturge-weber syndrome (sws) is a very rare congenital disorder that is manifested by facial capillary malformation (port wine stain) which may be associated with capillary – venous malformations affecting many parts such as the brain, eyes facial skin and mucosa and also airways. in this report we present an unusual 28 years old female case of sws that presented with signs and symptoms of sudde...

intracranial lipomas are congenital malformations. these uncommon lesions have an incidence of 0.1 to 1.7% of all intracranial tumors. most cases are located at midline and 5% are along the sylvian fissures. if symptomatic, seizures are the most common symptom. these tumors are slow growing and have favorable outcome. we report a case of a 25-year-old man whose ct and mri revealed a lesion in r...

background: imaging studies performed in research centers suggest a high prevalence of brain structural abnormalities in patients with epilepsy. however, the results of research studies may not be directly applicable to general clinic, because they may perform on patients with high probability of cerebral abnormalities. on the other hand, more advanced modalities are likely to be used in resear...

How the brain adapts to absence of sensory inputs and motor outputs from early development is a key question in neuroscience. While deprivation has long been known trigger changes cortical maps cortex, e.g. due blindness [1], deafness [2] or arm malformation [3], there an ongoing debate on their functional relevance. For example, using fMRI, we have previously reported that deprived sensorimoto...

A developmentally delayed 28-month-old male toddler was referred to us for brain MRI. Imaging revealed corpus callosum dysgenesis, forniceal hypoplasia, vermian hypoplasia, and hypothalamic dysmorphism characterized by tuber cinereum diverticula. Subsequent chromosomal microarray showed an Xq21 deletion. We present a case of Xq21 deletion syndrome with midline brain anomalies and a novel hypoth...

OBJECTIVE To determine the imaging and demographic characteristics of intracranial haemorrhages, which are subsequently found to be due to an underlying intracranial vascular malformation (IVM). METHODS We compared the demographic and brain imaging characteristics of adults presenting with intracranial haemorrhage, subsequently found to be due to a brain arteriovenous malformation (BAVM), dur...

Holoprosencephaly (HPE) is the most common malformation of the embryonic forebrain in humans. Although HPE occurs along a continuous spectrum, it has been categorized into four types from most severe to least severe: alobar, semilobar, lobar, and middle interhemispheric (MIH) variant. Facial malformations are often associated with HPE and usually correlate with the severity of brain malformatio...

BACKGROUND AND PURPOSE Bilateral posterior PNH is a distinctive complex malformation with imaging features distinguishing it from classic bilateral PNH associated with FLNA mutations. The purpose of this study was to define the imaging features of posterior bilateral periventricular nodular heterotopia and to determine whether associated brain malformations suggest specific subcategories. MAT...

Central nervous system infection is a rare complication of endovascular procedures. We report a 21-year-old woman presented with headache, nausea, vomiting, and right-sided hemiparesis 4 months after endovascular embolization of cerebral arteriovenous malformation. Investigations led to the diagnosis of multiple brain abscesses. This is the sixth case report of brain abscess following endovascu...