نتایج جستجو برای: brain mitochondria
تعداد نتایج: 516683 فیلتر نتایج به سال:
Resveratrol (3,5,4'-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondr...
Cardiac arrest induces whole-body ischemia, which causes damage to multiple organs. Understanding how each organ responds to ischemia/reperfusion is important to develop better resuscitation strategies. Because direct measurement of organ function is not practicable in most animal models, we attempt to use mitochondrial respiration to test efficacy of resuscitation on the brain, heart, kidney, ...
Manganese shares the uniport mechanism of mitochondrial calcium influx, accumulates in mitochondria and is cleared only very slowly from brain. Using dual-label isotope techniques, we have investigated both Mn2" and Ca2" mitochondrial efflux kinetics. We report that (1) there is no significant Na+-dependent Mn2" efflux from brain mitochondria; (2) Mn2" inhibits both Na+-dependent and Na+-indepe...
Introduction: Previous studies and our works have indicated several cation channels in the rat brain mitochondrial inner membrane. In this work, we report the single-channel characterization of a cation channel from the rat brain mitochondrial inner membrane incorporated into a planar lipid bilayer. Methods: After removing and homogenizing the adult rat brain, its supernatant was centrifuged...
The brain mitochondrial system is of a special interest because of the high concentration of mitochondria in the synaptic regions of neurons. Klee and Sokoloff (1965) have demonstrated the occurrence of protein synthesis in brain mitochondria. Campbell et al. (1966) have isolated two distinct cell-free protein synthesizing systeins from immature rat brain, one localized in purified ribosomes, t...
It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important role in, for example, lipid synthesis, calcium homeostasis, and apoptotic signaling. Perturbation of MAM function has previously been suggested in Al...
Parkinson's Disease Like stars in a brain that are “wider than the sky”, astrocyte-derived extracellular vesicles illuminate intercellular space, landing on injured neurons to protect their mitochondria. This cover features work by Bianca Marchetti, Nunzio Iraci, and co-workers article 2201203. Mouse regions involved disease (PD, top): Striatum (blue), ventral midbrain (green). Region-specific ...
Brain mitochondria are relatively resistant to calcium-induced mitochondrial permeability transition (MPT), with heterogenic response to the insult. The cause for this heterogeneity is not clear, so we studied the distribution of a key regulator of the MPT, cyclophilin D (cypD), within the rat brain by using immunohistology and Western blotting. Motor and parietal cortex, hippocampus, striatum,...
Tricyclodecan-9-yl-xanthogenate (D609) has in vivo and in vitro antioxidant properties. D609 mimics glutathione (GSH) and has a free thiol group, which upon oxidation forms a disulfide. The resulting dixanthate is a substrate for glutathione reductase, regenerating D609. Recent studies have also shown that D609 protects brain in vivo and neuronal cultures in vitro against the potential Alzheime...
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