Background and Purpose Hyponatremia is a common complication after subarachnoid hemorrhage. In this study we investigated the relations among hyponatremia, plasma natriuretic peptides, and antidiuretic hormone concentrations after subarachnoid hemorrhage. Methods Blood samples for radioimmunoassay measurement of plasma brain natriuretic peptide-like immunoreactivity, atrial natriuretic peptide-...

AIMS The degree of systolic dysfunction does not always correlate with functional impairment in patients with congestive heart failure. In contrast, diastolic dysfunction correlates well with functional impairment. In heart failure, both elevation of N-terminal proatrial natriuretic peptide and B-type natriuretic peptide are markers of a poor prognosis. METHODS We investigated 32 patients (26...

1024x768 normal 0 false false false en-us x-none fa background : heart failure is a common health problem with poor prognosis. the gold standard for diagnosis is echocardiography but it is not always reachable, especially in emergency conditions. nt-pro-brain natriuretic peptide (nt-probnp) is a novel indicator for the diagnosis of heart failure and is being used in routine tests in emergency r...

BACKGROUND Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to prove it. Unsuspected proadrenergic effects might oppose the anticipated benefits of natriuretic peptides. METHODS AND RESULTS We investigated whether natriuretic peptides induce catecholamine release in isolated hearts, symp...

Natriuretic peptides and nitric oxide play important roles in cardiovascular and renal physiology and disease. The natriuretic peptides - atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide - comprise a family of proteins that participate in the integrated control of intravascular volume and arterial blood pressure. The natriuretic peptides differentially bind ...

Background: Increased plasma levels of brain natriuretic peptide (BNP) have been identified as predictors cardiac dysfunction and prognosis in congestive heart failure ischemic disease. In severe sepsis patients, however, no information is available yet about the prognostic value peptides Egyptian patients. Aim: The aim present work to study relationship between amino-terminal pro-BNP, C-reacti...

We investigate the interaction of atrial natriuretic peptide (ANP) brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) with their receptors (NPRA, NPRB and NPRC), as well as the proportion and localization of those receptors in the rat ciliary body. Binding assays and affinity cross-linking experiments demonstrated the presence of the NPRC receptor type. However, the three natr...

Historical perspective A series of experiments done in the mid 1950s established the heart as an endocrine organ. First, Kisch and colleagues detected secretory granules in guineapig atria. Henry and Pearce subsequently described increased urinary flow after balloon stretch of the canine left atrium. In an experiment done 25 years later, de Bold injected homogenised atrial tissue into rats and ...

Assays for natriuretic peptides have received considerable attention as potential screening tests for congestive heart failure and left ventricular dysfunction. However, information regarding the impact of age, sex, and other physiologic characteristics on natriuretic peptide levels is limited. We examined a healthy reference sample of 911 subjects (mean age 55 years, 62% women) from the Framin...