We present the case of a 52 years old woman who developed multiple brain metastasis after cystectomy with anterior exenteration and chemotherapy. She received whole-brain radiotherapy with 20 gray in 5 sessions. On magnetic resonance imaging 8 weeks after radiotherapy she showed a regression of some lesions while others responded only partially. This case-report and a review of the literature s...

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shor...

Glioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy radiotherapy. Surgery, radiotherapy with temozolomide are only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑Nep; an EZH2 inhibitor) panobinostat (a histone deacetylase being tested in vitro, together temozolomide. The present study...

Abstract AIMS Cerebral metastases from extra-cranial primary cancer carries a poor prognosis. For patients in whom surgical resection or SRS are not suitable, local control rates poor. There is considerable debate surrounding the value of whole brain radiotherapy this patient cohort terms control, survival and functional status. We aimed to measure receiving at Norfolk Norwich University Hospit...

Background: Children with brain tumors experience potential neurologic complications when are treated radiotherapy, especially if done frequently under anesthesia. Objectives: This study aimed to evaluate the associated anesthesia in pediatrics radiotherapy Methods: cross-sectional consisted of 133 pediatric patients a tumor who needed for performing and were referred Omid Charity Hospital Imam...

Medulloblastoma and primitive neuroectodermal tumors (PNETs) are the most common malignant brain tumors in children. The concern for late sequelae of neuraxis irradiation and the obligation to improve disease-free survival in children who harbor malignant brain tumors has led to the additional provision of systemic chemotherapy to standard- and reduced-dose radiotherapy, as well as to the evalu...