background: the first three years of life have a pivotal role in growth and development of infants. extra-uterine environment largely affects brain development of infants during the first year of life.however,no specific programs are available for brain development stimulation in foster homes. aim: this study aimed to evaluate the effects of motor development stimulation package on anthropometr...

introduction: working memory plays a critical role in cognitive processes which are central to our daily life. neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (dlfpc). this study was aimed to assess whether bilateral modulation of the dlpfc using a noninvasive brain stimulation, namely transcranial di...

Brain-computer interfaces (BCIs) are an emerging strategy for spinal cord injury (SCI) intervention that may be used to reanimate paralyzed limbs. This approach requires decoding movement intention from the brain control movement-evoking stimulation. Common methods use spike-sorting and require frequent calibration high computational complexity. Furthermore, most applications of closed-loop sti...

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were sub...

Abstract Brain stimulation has emerged as a novel therapy for ischemic stroke, major cause of brain injury that often results in lifelong disability. Although previous vitro and rodent studies have demonstrated neuroprotection using electrical or sensory acutely after few these been replicated humans due to significant scale anatomical differences, addition limited understanding stimulation-ind...

Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- ad...

Abstract Deep brain stimulation (DBS) of the anterior limb internal capsule (ALIC) has shown promise as a therapy for refractory obsessive-compulsive disorder (OCD) and major depressive (MDD). DBS currently is ‘open-loop’ with parameters remaining fixed over time. In contrast, ‘closed-loop’ delivers only when biomarker target symptom state indicates it needed. One challenge to development close...

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were sub...

Background: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control of seizures in patient with pharmacoresistance to drugs. So, the aim of present study was designed to determine the effect of a sub effective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. Material and Methods: One tripolar ele...