Background: Presurigical planning for glioma tumor resection and radiotherapy treatment require proper delineation of tumoral and peritumoral areas of brain. Diffusion tensor imaging (DTI) is the most common mathematical model applied for diffusion weighted MRI data. Neurite orientation dispersion and density imaging (NODDI) is another mathematical model for DWI data modeling.Objective: We stud...

introduction: skull base meningiomas constitute a large proportion of the meningiomas, which are the most common benign brain tumors. the treatment of skull base meningiomas is specially challenging and controversial due to the proximity of these tumors to the vital brain structures. radiosurgery is now emerging as an efficient alternative treatment modality which involves the ablation of tumor...

Introduction: Gamma Knife is an instrument specially designed for treating brain disorders. In Gamma Knife, there are 201 narrow beams of cobalt-60 sources that intersect at an isocenter point to treat brain tumors. The tumor is placed at the isocenter and is treated by the emitted gamma rays. Therefore, there is a high dose at this point and a low dose is delivered to the normal tissue surroun...

Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor ref...

Intracranial tumors are a type of cancer that grows spontaneously inside the skull. Brain tumor is cause for one in four deaths. Hence early detection important. For this aim, variety segmentation techniques available. The fundamental disadvantage present approaches their low accuracy. With help magnetic resonance imaging (MRI), preventive medical step and evaluation brain done. Magnetic (MRI) ...

Abstract Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, emphasis has recently been switched toward innovative techniques modulating immune response against tumors and their microenvironments (TME). Cancerous cells eleven hallmarks which make it distinct from normal ones, among is ev...

Background& Objective: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment  and appears to be capable to distinguish between malignant neo-vasculature and normal vesse...

Brain Tumor is an unwanted mass when cells grow abnormally. It puts pressure on certain areas of the brain which dangerously affects its functioning. For severe tumors like malignant, surgery not a good option because they do have definite boundaries and are closely attached with other healthy tissues brain. So chemotherapy preferable in this case to avoid damaging cells. The primary intention ...

Neurofibromatosis type 2 is an inherited disease. The main manifestation of the disease is the development of symmetric, non-malignant brain tumors in the region of the cranial nerve VIII usually as schwannoma. We report here a 20-year-old woman with primary intracranial malignant nerve sheath tumor located in the left cerebellopontine angle. Histologically, the tumor showed malignant spindle c...