Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle, caused by multiple pathogens that become more virulent in response to stress. As clinical signs often go undetected and various preventive strategies failed, identification of genes affecting BRD is essential for selection for resistance. Selective DNA pooling (SDP) was applied in a genome wide a...

We aimed to define the chronically altered gene expression signature of traumatic brain injury (TBI-sig) to discover novel treatments to reverse pathologic gene expression or reinforce the expression of recovery-related genes. Genome-wide RNA-sequencing was performed at 3 months post-TBI induced by lateral fluid-percussion injury in rats. We found 4964 regulated genes in the perilesional cortex...

Susceptibility to bovine respiratory disease (BRD) is multi-factorial and is influenced by stress in conjunction with infection by both bacterial and viral pathogens. While vaccination is broadly used in an effort to prevent BRD, it is far from being fully protective and cases diagnosed from a combination of observed clinical signs without any attempt at identifying the causal pathogens are usu...

BACKGROUND The diagnostic tools for bovine respiratory disease diagnosis include clinical inspection, thoracic auscultation, and ultrasonography. HYPOTHESIS Thoracic auscultation and clinical examination have limitations in the detection of lung consolidation in dairy calves. ANIMALS Prospective cohort of 106 preweaned calves from 13 different dairy herds (10 with a history of active bovine...

In this study, we determined the prevalence of bovine respiratory disease (BRD)-associated viral and bacterial pathogens in cattle and characterized the genetic profiles, antimicrobial susceptibilities, and nature of antimicrobial resistance determinants in collected bacteria. Nasopharyngeal swab and lung tissue samples from 68 BRD mortalities in Alberta, Canada (n = 42), Texas (n = 6), and Neb...

Python egg brooding typifies parental care because it consists of multiple behaviours that provide for multiple developmental needs. For example, tightly coiling around the eggs benefits embryonic water balance, but periodic female postural adjustments improve embryonic gas exchange. Regardless of these postural adjustments, egg brooding creates a hypoxic intra-clutch environment that constrain...

Regulatory mechanisms underlying γH2AX induction and the associated cell fate decision during DNA damage response (DDR) remain obscure. Here, we discover a bromodomain (BRD)-like module in DNA-PKcs (DNA-PKcs-BRD) that specifically recognizes H2AX acetyl-lysine 5 (K5ac) for sequential induction of γH2AX and concurrent cell fate decision(s). First, top-down mass spectrometry of radiation-phenotyp...

Bovine respiratory disease (BRD) research has provided significant understanding of the disease over the past 26 years. Modern research tools that have been used include monoclonal antibodies, genomics, polymerase chain reaction, immunohistochemistry (IHC), DNA vaccines and viral vectors coding for immunogens. Emerging/reemerging viruses and new antigenic strains of viruses and bacteria have be...

Die 1948 im Auftrag der US-amerikanischen Militärregierung gegründete Zeitschrift Der Monat war ein intellektueller Brennspiegel jungen Bundesrepublik, in dem die politischen Deutungskonflikte - mit Fokus auf den Nationalsozialismus, Sowjetkommunismus und Zukunft westlichen Welt ausgetragen wurden. Zu ihrem Renommee trug bei, dass sie zahlreiche prominente Autoren wie Hannah Arendt, Raymond Aro...

5-10% but was sometimes found when the level was 10-25%. Though relating to a different therapeutic problem their results may be relevant. The average daily dose of 72 mg. of phenindione in this trial was less than the mean daily dose of 108 mg. used in the M.R.C. long-term anticoagulant trial (Report to Medical Research Council, 1959, 1964). The moderate anticoagulant effect might explain the ...