The Nijmegen breakage syndrome is a rare autosomal recessive chromosomal instability disorder characterized by early growth retardation, congenital microcephaly, immunodeficiency, borderline mental development, and a high tendency to lymphoreticular malignancies. Most Nijmegen breakage syndrome patients are of Slavonic origin, and all of them known so far carry a founder homozygous 5 nucleotide...

Information from a reference population of animals with accurate breeding values is used to predict the genetic merit test for which such phenotypic information not available. For crosses, these procedures may be proportion genes one breed in crossbred cattle when sets genotypes purebred are available as reference. The genomic composition 6326 HF (as population) performing Gujarat was determine...

Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks. However, direct and genome-wide evidence that collapsed replication forks give rise to chromosome breakage is still lacking. Previously we showed that a yeast replication checkpoint mutant mec1-1, after transient ex...

It has been observed that the pattern of particle impact breakage in two-dimensional systems is a result of two mechanisms. AMechanism IB accounts for the breakage induced by the stresses that appear in unbroken particles. AMechanism IIB breakage is due to the buckling of the Mechanism I fragments. The purpose of this paper is to try and understand the parameters that govern the magnitude of th...

This paper introduces a price-fixing policy to be applied to software procurement general contractual agreements occurring between customers and suppliers. The price-fixing policy aims at overcoming the limits and problems of “Function Point fixed-price” mechanisms. Basically the policy derives from a practical application of the "Business Function Point" (BFP) technique. Assigning the price of...