TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with ...

The influence of surface roughness on the slip behaviour of a Newtonian liquid in steady planar shear is investigated using three different approaches, namely Stokes flow calculations, molecular dynamics (MD) simulations and a statistical mechanical model for the friction coefficient between a corrugated wall and the first liquid layer. These approaches are used to probe the behaviour of the sl...

Membrane distillation (MD) is an interesting process for desalination; however high thermal energy consumption remains one of the main obstacles in its widespread adoption. The current study presents multipass hollow fiber membrane modules to improve efficiency MD process. Fundamentally three module designs are considered: conventional shell and tube (fiber) pass (A), 1 multiple passes (B/C) eq...

The three massless active (doublet) neutrinos may mix with two heavy and one light sterile (singlet) neutrinos so that the induced masses and mixings among the former are able to explain the present data on atmospheric and solar neutrino oscillations. If the LSND result is also to be explained, one active neutrino mass eigenstate must mix with the light sterile neutrino. A specific model is pro...

This study supplemented the way of sex determination fish based on regression relationship some morphological indicators Mystus mysticetus. A total 425 specimens were collected by trawl nets at Cai Rang - Can Tho and Long Phu Soc Trang from January to July 2022. After collection, transferred laboratory determine their length (TL), standard (SL), eye diameter (ED), distance (DE), body height (BD...

We use QCD sum rules for the three point function of a pseudoscalar and two nucleonic currents in order to estimate the charge dependence of the pion nucleon coupling constant gNNπ coming from isospin violation in the strong interaction. The effect can be attributed primarily to the difference of the quark condensates < ūu > and < d̄d >. Assuming that the π is a pure isostate we obtain for the s...

Electron attachment dynamics of excess electron in water cluster (H2O)n (n = 2 and 3) have been investigated by means of full-dimensional direct ab initio molecular dynamics (MD) method at the MP26-311++G(d,p) level. It was found that the hydrogen bond breaking due to the excess electron is an important process in the first stage of electron capture in water trimer. Time scale of electron local...

Let D = (V,E) be a digraph and u, v ∈ V. The metric maximum distance is defined by md(u,v) max {d⃗(u,v), d⃗(v,u)}, where d⃗(u,v) denote the length of shortest directed u − path in D. m-eccentricity vertex mecc(v) {md(v,u) : V(D)}. m-center mC(D) strongly connected consists all vertices with minimum m-eccentricity, m-periphery mPer(D) relationship between two digraphs their lexicographic product st...

We develop a novel technique for simulation of the mechanics of micron scale solid systems Coarse Grained Molecular Dynamics CGMD It captures the important atomistic e ects without the computational cost of conventional molecular dynamics MD The CGMD equations of motion are derived directly from nite temperature MD through a statistical coarse graining procedure so they agree with MD as the mes...

ahmad matar – iraqi satirical poet – attempted to save the arabic governments from imperialistic yoke who tried to arrogate nations’ freedom. his poetic language has sensible characteristics which the poet applies them in order to invite people to freedom and liberty. norm breaking is one of his poetry’s features. the present article tries to survey the vocal norm breaking – including rhyme, rh...