W ell, there wasn't much doubt about this year's winner. Unlike some past Breakthroughs, this one unfolded very much in the public eye, and the arguments that sometimes ensue when Science's News and Editorial staffs converge for the selection were pretty tame this time around. The two Mars rover missions—well advertised by NASA beforehand— succeeded where two other recent attempts had failed, a...

cines and the template described in An-derson and Hanson [2]. Blower falsely claims (e.g., see [3], p. 118) that her 1993 and 1994 articles included , to quote, " the first transmission model of HIV vaccines to assess the potential epidemic-level impact of imperfect vaccines. " This is incorrect—the 1991 Nature article by Anderson et al. was the first. To the Editor—Zygomycosis is an inva-sive ...

Heart failure with preserved ejection fraction (HFPEF), a clinical syndrome where heart failure (HF) exists in the presence of normal or near-normal left ventricular ejection fraction (LVEF), accounts for up to half of all HF patients. However, in contrast to heart failure with reduced ejection fraction (HFREF), where therapeutic advances have significantly improved outcomes over the last two d...

BACKGROUND We previously demonstrated that persistent and long-standing persistent atrial fibrillation is maintained by activation emanating from foci and breakthrough sites of different cycle lengths (CLs). The purpose of this study was to characterize the behavior of focal and nonrandom breakthrough activation identified during high-density mapping of atrial fibrillation in these patients. ...

Breakthrough seizures are often encountered in patients with well-controlled epilepsy for no obvious reason. We report a case of a breakthrough seizure after temporal lobectomy secondary to topical administration of essential oils. We recommend inquiring about the use of essential oils in patients with well-controlled epilepsy who experience breakthrough seizures.

Diphenylmethane diisocyanate (MDI) is a sensitizing chemical that can cause allergic contact dermatitis and asthma. Protective gloves and clothing are necessary to prevent skin exposure. Breakthrough times are used for the selection of chemical protective gloves and clothing. In the EN 374-3:2003 European standard, breakthrough time is defined as the time in which the permeation reaches the rat...

We thank Dr. Blennow and Dr. Kalin for their comments (1) relating to our recent paper (2). They argue that some of the cases included in our study as breakthrough fungal infections occurring while patients were taking posaconazole prophylaxis are not cases of “invasive” fungal infections (IFIs). To clarify, we agree that case 4 (culture-proven oral candidiasis), case 7 (culture-proven urinary ...