Oncotype DX Breast Recurrence Score is a prognostic and predictive assay of 21 genes, initially designed for therapy planning in patients with hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, lymph node-negative or node-positive (maximum 3 nodes involved), early-stage breast cancer. The 9-year risk distant recurrence its role estimating chemotherapy benefit has b...

Over the past three decades, numerous patients with breast cancer succumbed to cancer metastasis and recurrence, while, the exact mechanisms underlying this malignancy, and the potential biomarkers for prognosis prediction remain elusive. It was previously demonstrated that phosphorylated RAC-α serine/threonine-protein kinase (pAkt) and Beclin 1 was associated with cancer metastasis, and recurr...

Breast cancer is an important health problem that especially affects women. In breast where surgical procedures are the primary treatment modality, breast-conserving surgery with radiotherapy becoming more popular than mastectomy. Re-excision may be necessary in cases of recurrence or positive margins. Damage to cavity formed due scar formation old operation lodge make dissection difficult. Fai...

background: breast cancer is the most common type of cancer in women demanding time and accurate diagnosis to take remedial measures to treat. objective: comparing the diagnostic capability of the computer regulation thermography (crt), as a novel and safe dignostic procedure, with common clinical examination and imaging methods including sonography and mammography for diagnosing breast cancer ...

Breast Cancer has become the common cause of death among women. Due to long hours invested in manual diagnosis and lesser diagnostic system available emphasize the development of automated diagnosis for early diagnosis of the disease. Our aim is to classify whether the breast cancer is benign or malignant and predict the recurrence and non-recurrence of malignant cases after a certain period. T...

BACKGROUND Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence. METHODS Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III...

One of the important tasks in cancer research is to identify biomarkers and build classification models for clinical outcome prediction. In this paper, we develop a CyNetSVM software package, implemented in Java and integrated with Cytoscape as an app, to identify network biomarkers using network-constrained support vector machines (NetSVM). The Cytoscape app of NetSVM is specifically designed ...

The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains unclear. The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer. A dataset for 254 subjects with breast cancer (220 nonrecurrent and 34 recurrent) was used in individual and cumulated receiver operating charact...