AIMS AND METHODS To describe patients with decreased libido during use of a HMG-CoA-reductase-inhibitor, and to discuss causality and pharmacological hypotheses for this association by analysis of the adverse drug reactions (ADR) database of the Netherlands Pharmacovigilance Centre Lareb. RESULTS Eight patients were identified as having decreased libido during use of statins. In two of these ...

Although ego depletion effects have been widely observed in experiments in which participants perform consecutive self-control tasks, the process of ego depletion remains poorly understood. Using the strength model of self-control, we hypothesized that chronic ego depletion adversely affects goal adherence and that mental effort and motivation are involved in the process of ego depletion. In th...

In a review of the literature on the ego-ideal my impression has been that this concept has been placed in the position of a stepchild of the structural model of the mind, falling somewhere between the ego and the super-ego, and yet remaining loosely linked to both. Authors such as Jacobson (1954), Hartmann and Lowenstein (1962), Sandler (1963), and Schafer (196 7), have regarded the ego-ideal ...

Self-affirmation is known to reduce defensive psychological responses to ego threats. The current experiment tested the hypothesis that self-affirmation reduces physiological responses to a form of ego threat-interpersonal evaluation. Participants wrote an essay and received either neutral or insulting evaluative feedback about their essay, ostensibly from another participant. Then participants...

Cognitive research on metaphoric concepts of time has focused on differences between moving Ego and moving time models, but even more basic is the contrast between Ego- and temporal-reference-point models. Dynamic models appear to be quasi-universal cross-culturally, as does the generalization that in Ego-reference-point models, FUTURE IS IN FRONT OF EGO and PAST IS IN BACK OF EGO. The Aymara l...

BACKGROUND Cell-fate determination requires that cells choose between alternative developmental pathways. For example, germ cells in the nematode worm Caenorhabditis elegans choose between mitotic and meiotic division, and between oogenesis and spermatogenesis. Germ-line mitosis depends on a somatic signal that is mediated by a Notch-type signaling pathway. The ego-1 gene was originally identif...