نتایج جستجو برای: bse function

تعداد نتایج: 1215102  

Journal: :Biological chemistry 2007
Wolfgang J Philipp Darlene Groth Kurt Giles Pavel Vodrazka Heinz Schimmel Muriel Feyssaguet Reet Toomik Pascal Schacher Awad A Osman Ingolf Lachmann Angus Wear Jean-Noel Arsac Stanley B Prusiner

Rapid BSE tests are widely used diagnostics in veterinary medicine and more than 11 million tests are applied worldwide. The evaluation of new rapid BSE tests and the quality assurance of approved BSE tests pose a challenge owing to the natural scarcity of BSE-infected bovine brainstems and regional variations in prion titer. Transgenic mice expressing bovine prion protein (Tg4092) offer an alt...

2013
Catherine E Vrentas Justin J Greenlee Thierry Baron Maria Caramelli Stefanie Czub Eric M Nicholson

BACKGROUND Transmissible Spongiform Encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in cervids, transmissible mink encephalopathy (TME), and bovine spongiform encephalopathy (BSE), are fatal diseases of the nervous system associated with accumulation of misfolded prion protein (PrP(Sc)). Different strains of TSEs exist, associated with different PrP(Sc) confor...

2010
Timm Konold A Robin Sayers Amanda Sach Gemma E Bone Steven van Winden Gerald AH Wells Marion M Simmons Michael J Stack Angus Wear Steve AC Hawkins

BACKGROUND Various clinical protocols have been developed to aid in the clinical diagnosis of classical bovine spongiform encephalopathy (BSE), which is confirmed by postmortem examinations based on vacuolation and accumulation of disease-associated prion protein (PrPd) in the brain. The present study investigated the occurrence and progression of sixty selected clinical signs and behaviour com...

2011
John Chambers Ahmet Fuat Theresa McDonagh Mark Monaghan

 John Chambers (British Society of Echocardiography)  Cardiothoracic Centre, Guy's and St Thomas Hospitals, London  Ahmet Fuat (Primary Care Cardiovascular Society)  Strat Liddiard (CHD collaborative) Poole PCT  Theresa McDonagh (British Heart Failure Society) Cardiology Department, Western Infirmary, Glasgow  Mark Monaghan (BSE) Cardiac Department, King's College Hospital, London  Petro...

Journal: :Nature 1990

Journal: :Pharmaceutical Regulatory Affairs: Open Access 2014

2010
Yoshifumi Iwamaru Morikazu Imamura Yuichi Matsuura Kentaro Masujin Yoshihisa Shimizu Yujing Shu Megumi Kurachi Kazuo Kasai Yuichi Murayama Shigeo Fukuda Sadao Onoe Ken’ichi Hagiwara Yoshio Yamakawa Tetsutaro Sata Shirou Mohri Hiroyuki Okada Takashi Yokoyama

We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.

2011
Laura Pirisinu Sergio Migliore Michele Angelo Di Bari Elena Esposito Thierry Baron Claudia D’Agostino Luigi De Grossi Gabriele Vaccari Umberto Agrimi Romolo Nonno

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE ...

Journal: :BMC Veterinary Research 2008
Lourens Heres Dick J Brus Thomas J Hagenaars

BACKGROUND In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. RESULTS We have found three spatial case clusters in t...

2016
Gemma B. Arriola Daniel Ryan

Breast Self-Examination (BSE) is always thought to be done by most women only. However, men are also susceptible to breast cancer and as such, also needs to perform Breast Self-Examination (BSE). In this study, the awareness, compliance; and confidence of the participants on BSE was done among 496 students, between male and female participants, of different year levels and from different colleg...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید