Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination given opportunities to elegantly make pharmaceutical ingredients. Indeed, these at forefront of both stages drug development, medicinal chemistry, process chemistry. On one hand, chemists a resource derivatize core compound arrive scaffold rapidly. other ...

In this study, new Cu(II)/chitosan-based systems were designed via (i) the treatment of chitosan with sodium sulfate (1a) or acetate (1b); (ii) coating 1a 2a a hyaluronate layer (2a and 2b, correspondingly); (iii) cholesterol–chitosan conjugate (3a) (3b); (iv) succination 1b to afford 4a 4b 2b yield 5a 5b. The catalytic properties elaborated in various organic transformations evaluated. use cop...

Two new hole transporting materials, named HTM 1A and HTM 1B, were designed and synthesized in significant yields using the well-known Buchwald Hartwig and Suzuki cross- coupling reactions. Both materials showed higher decomposition temperatures (over 450 °C) at 5% weight reduction and HTM 1B exhibited a higher glass transition temperature of 180 °C. Red phosphorescence-based OLED devices were ...

Considerable efforts have been undertaken by numerous groups in academia and industry over the past decade to expand the repertoire of coupling reagents in palladium(0)-catalyzed cross-coupling reactions. In particular, alkenyl phosphates and tosylates have proven their worth in various cross-coupling reactions, such as the Stille, Suzuki, 3] Negishi, Kumada, Sonogashira, b,e,f,5] Buchwald–Hart...

Two new hole transporting materials, 2,7-bis(9,9-diphenylacridin-10(9H)-yl)-9,9' spirobi[fluorene] (SP1) and 2,7-di(10H-phenothiazin-10-yl)-9,9'-spirobi[fluorene] (SP2), were designed and synthesized by using the Buchwald-Hartwig coupling reaction with a high yield percentage of over 84%. Both of the materials exhibited high glass transition temperatures of over 150 °C. In order to understand t...

Halogenverbrückte Methylnaphthyl (MeNAP)-Palladiumdimere werden als vielseitige-Pd-Quellen vorgestellt, die sich ideal für Entwicklung katalytischer Methoden und präparativer organischer Synthesen eignen. Durch einfaches Mischen mit Phosphin- oder Carben-Liganden sie in situ definierte, monoligierte Komplexe umgewandelt. Ihre katalytische Aktivität wurde anspruchsvollen Buchwald-Hartwig-, Heck-...

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. To enable minimally invasive studies of proteins in their native context, it is desirable to tag proteins with small, bright reporter groups. Recently, our lab described PRIME technology (for PRobe Incorporation Mediated by Enzymes) for such tagging [1-3]. An engineered variant...

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. To enable minimally invasive studies of proteins in their native context, it is desirable to tag proteins with small, bright reporter groups. Recently, our lab described PRIME technology (for PRobe Incorporation Mediated by Enzymes) for such tagging [1-3]. An engineered variant...