Results from the studies discussed in this article suggest that alcohol (EtOH) intoxication is a major public health problem. While the effects of injury and EtOH intoxication independent of each other have been studied in detail, only few studies have evaluated the effect of a combined insult of EtOH intoxication and burn injury on host defense. An analysis of the studies conducted in the clin...

OBJECTIVE To describe, for the first time, distribution (by geography, age, sex) and time trends in burn injury in England and Wales over the period that the international Burn Injury Database (iBID) has been in place. SETTING Data from the iBID for the years 2003-2011 were used for a retrospective descriptive observational study of specialised services workload and admissions in England and ...

Inhalation injury remains a significant source of morbidity and mortality in children with burn injury. The purpose of this study is to analyze the incidence, demographic characteristics, and outcomes for children who have sustained burn injury at one of four regional pediatric burn centers. A retrospective review of children aged 0 to 18 years admitted to one of four pediatric burn centers fro...

RATIONALE Cytokines are central mediators of the immune-inflammatory response to injury and subsequent multiple organ dysfunction syndrome (MODS). Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically. METHODS A prospective database of trauma patients admitted between May 2004 and Sept...

To the Editor-The appropriate review, "Anesthesia for Major Thermal Injury," overstates the contraindication to succinylcholine on pages 754 (". . . succinylcholine . . . >24 h after burn injury is unsafe") and 755 (". . . safe only within 24 h of a burn").' The safe period for burn patients is 6-7 days after a burn injury, whereas that for denervation is 4 days. Studies beginning 6 days after ...

Marked hypersensitivity to heat and mechanical (pressure) stimuli develop after a burn injury, but the neural mechanisms underlying these effects are poorly understood. In this study, we establish a new mouse model of focal second-degree burn injury to investigate the molecular and cellular basis for burn injury-induced pain. This model features robust injury-induced behavioral effects and tiss...

S ince 1952, the US Army Institute of Surgical Research (USAISR) Burn Center has provided comprehensive care for patients who have sustained severe thermal trauma, inhalation injury, and other diseases related to burn trauma. The Army Burn Center serves the entire population encompassed by the military health care system as well as veterans and civilian emergency patients requiring burn center ...

Background: Severe immunosuppression occurs after large thermal burn and probably contributes substantially to patient morbidity and mortality.In this study we investigated the range and distribution of T-lymphocyte. Subsets CD3 (T cells) CD4 (T helper/inducer cell,.th ), CD8 (T suppressor /Cytotoxic cells ,TS/C), CD3 CD4/CD3CD8 ratio, CD19 (B cells) and CD16 (NK cells ) in patiens following th...

UNLABELLED Chemical burn injury meets the criteria of the American Burn Association for treatment at a specialized burn facility. Over a 51-year period, we have treated 276 patients with chemical burn injury including 146 white phosphorus injuries. In this study, we compare incidence, cause and outcome of chemical burn injury over time and review the management of white phosphorus injuries. M...

The classical tachykinin substance P (SP) has numerous potent neuroimmunomodulatory effects on all kinds of airway functions. Belonging to a class of neuromediators targeting not only residential cells but also inflammatory cells, studying SP provides important information on the bidirectional linkage between how neural function affects inflammatory events and, in turn, how inflammatory respons...