Two macrolide antibiotics, josamycin and erythromycin stearate, were administered orally to healthy, adult male volunteers for a comparative study of their pharmacological properties. In comparable doses, josamycin and erythromycin produced similar plasma concentrations, with similar half-lives and elimination constants. An initial loading dose of 1.5 g of josamycin produced greater peak concen...

Background and objectives: Plumeria rubra L. (Apocynaceae) is a deciduous shrub or small tree cultivated in subtropical and tropical countries.  Its bark is prescribed to treat amoebic dysentery,   dropsy, jaundice, scabies, gonorrhea, venereal affections and wounds. In the present research, we aimed to isolate and identify the chemical constituents of the bark of ...

The pharmaceutical industry requires the use of lubricants to prevent static electric buildup in the cohesive powders that are processed in manufacturing plants. In this report we examine the effects of common lubricant magnesium stearate on two flow properties, flow index and dynamic dilation, of lactose. We conducted two experiments using a gravitational displacement rheometer and a dynamic d...

Wood et al have reported that the stearate to oleate ratio in the lipids of erythrocyte membranes exceeds 1 0 both in healthy controls and in patients without cancer and is less than 10 in all patients with malignancies.' Similarly, the ratio is 1 0 or higher in patients without recurrent tumours and less than 10 in patients with recurrence. They suggested that this phenomenon might be caused b...

Ground calcium carbonate (GCC) was modified by starch with the aid of sodium stearate and sodium hexametaphosphate. The GCC was encapsulated within the complex. The effect of the dosages of sodium stearate and sodium hexametaphosphate on the coating weight of modified GCC and the complex utilization rate were studied. The SEM images of modified GCC were compared with that of unmodified GCC. The...

Polystyrene (PS) nanospheres with a monodisperse size distribution, positive surface charge and high molecular weight were successfully synthesized using various types of metal stearates in an aqueous NaOH medium. The diameter of the PS nanospheres was controlled from 80 to 450 nm by changing the type of metal stearate. It was also found that controlling the NaOH concentration in solution was i...

This experiment tested the influence of the lubricant magnesium stearate on the effectiveness of the drug acetaminophen in a mixture of glidants and excipients. There are many factors that can cause variation in the effectiveness of drugs in tablet form. Chief among them are the lubrication and glidant percentages, shear rate, tablet hardness and hydrophobicity. In order to allow the powder to ...

Upon platelet activation, free fatty acids are released at the stage of thrombus formation, but their effects on fibrin formation are largely unexplored. Our objective was to characterize the kinetic effects of fatty acids on thrombin activity, as well as the structural and mechanical properties of the resultant fibrin clots. Thrombin activity on fibrinogen was followed by turbidimetry and deta...

The synthesis and characterisation of two groups nonsymmetric dimers, the 1-(4-cyanobiphenyl-4‘−yloxy)-ω-(4-butyl, 4-(1-methylpropyl) or 4-t-butylanilinebenzylidene-4’−oxy)alkanes, 1-(4-cyanobiphenyl-4‘−yl)-ω-(4-butyl, are reported. length parity flexible spacer is varied. tert-butyl homologues show higher melting points than corresponding sec-butyl n-butyl substituted suggesting that chain bra...