Lipid metabolism is intimately linked to circadian mechanisms and light signaling. Deteriorated photic transduction because of retinal ganglion cell (RGC) loss occurring with glaucoma progression reduces perceived amplitude, causing disruption. To investigate associations RGCs, total cholesterol (TC), its low-density (LDL-C) high-density (HDL-C) fractions, triglycerides (TG) were measured, unde...

BACKGROUND/AIM Cardiovascular morbidity and mortality are markedly increased in chronic renal failure (CRF). The aim of this study was to evaluate lipid parameters and bioindices in patients with different stages of CRF. METHODS In 46 hemodialysed (HD), 50 CRF patients with II, III and IV stage of CRF (non-HD) and 48 control subjects triglycerides (TG), total cholesterol (C), HDL-C, urea, cre...

BACKGROUND It is indicated that non-HDL cholesterol and lipid ratios, including total/HDL cholesterol and LDL/HDL cholesterol ratios, are risk indicators with greater predictive value for coronary atherosclerotic progression or regression compared with conventional lipid profile. However, there have been few reports about the correlation between serum lipid profile with carotid intima-media thi...

OBJECTIVE Type 1 Gaucher disease (GD1) is an autosomal recessive lysosomal storage disorder associated with abnormal accumulation of glucocerebrosides. Plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) are decreased in GD1 patients. The effects of substrate reduction therapy (SRT) with miglustat on plasma lipids and athe...

the major lipoprotein classes are heterogenous. human serum high-density-lipoproteins (hdl) are separated into two major subfractions (hdl2, d=1.063-1.125 g/ml, hdl3, d=1.125-1.210 g/ml) by a simple double precipitation method. there was a strong inverse relation between hdl-cholesterol (hdl-c) and subfractions hdl2-c and hdl3-c with atherosclerosis. this study demonstrated that hdl-c (p<0.001)...

Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patientschr('39') health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-...

An interaction between smoking and antipsychotic medications could potentially affect treatment efficacy promote metabolic side effects. We investigated the contribution of status towards Positive Negative Syndrome Scale (PANSS) scores syndrome- related parameters (plasma lipid glucose concentrations, body mass index) among two groups unmedicated patients with psychosis from Croatian population...

BACKGROUND Prospective studies have examined the relationship between coronary artery disease and low plasma levels of high-density lipoprotein cholesterol (HDL-C). METHODS AND RESULTS We investigated the causes of hypoalphalipoproteinemia (HypoA; HDL-C <5th percentile) in 64 subjects (12 women and 52 men). Apolipoprotein AI-mediated cellular cholesterol and phospholipid efflux were measured ...

OBJECTIVE The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn). METHODS AND RESULTS Sixty nondiabetic adults with low HDL-C and MetSyn were randomized to PIO or matching placebo for 12 weeks. PIO increased HDL-C by 15% and...

BACKGROUND The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how SGLT-2 inhibitors affect LDL and HDL-C subspecies. METHODS This single center, open-label, randomized, prospective study included 80 patients with type 2 diabetes taking prescr...