Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. When Hh is absent, its receptor Patched (Ptc) represses Smoothened (Smo) signaling by an unknown catalytic mechanism that correlates with reduced Smo levels on the basolateral membrane. Ptc contains a sterol-sensing domain and is similar to the N...

Abstract Introduction Apolipoprotein B containing lipoproteins are atherogenic. There is evidence that with low plasma density lipoprotein cholesterol (LDL-C) levels residual vascular risk might be caused by triglyceride rich such as very-low (VLDL), chylomicrons and their remnants. We investigated the relationship between VLDL-cholesterol (VLDL-C) recurrent major adverse cardiovascular events ...

Regulation of lipid metabolism during infection is thought to be part of host defense, as lipoproteins neutralize endotoxin (LPS) and viruses. Gram-positive infections also induce disturbances in lipid metabolism. Therefore, we investigated whether lipoproteins could inhibit the toxic effects of lipoteichoic acid (LTA), a fragment of gram-positive bacteria. LTA activated RAW264.7 macrophage cel...

The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2)...

Observational epidemiological studies have associated plasma lipid concentrations with risk for coronary heart disease (CHD), but these studies cannot distinguish cause from mere correlation. Human genetic studies, when considered with the results of randomized controlled trials of medications, can potentially shed light on whether lipid biomarkers are causal for diseases. Genetic analyses and ...

Background: Acne vulgaris is a common dermatological condition and is known to be caused by many factors. Presence of obesity causes a number of changes in the skin barrier function as well as in lipid profile. Aims & Objective: The objective of this study is to find out the relevance of lipids and lipoproteins levels in obese and non-obese acne patients and compare it with healthy controls. Ma...

although there are many evidences regard to the relationship between serum thyroid hormones, cholesterol, triglyceride and lipoproteins in different animals, but there are limited references in dogs. the aim of this study was to determine the correlation between thyroid hormones and concentrations of serum lipid and lipoprotein profiles, and also to detect relationship between the measured para...

introduction: in order to study the effects of turpentine oil on the concentration of lipids and lipoproteins of rabbit ( as an animal model for human studies )35 healthy female rabbits were chosen and then randomly allocated into 13 groups. different percents of turpentine oil and other oil compounds like vegetable oil, cholesterol and animal oil were given to each group ( 5 rabbits ) separate...