Mammary gland cancer is a serious worldwide medical problem. Chemoprevention is rapidly growing area of oncology. The strategy of chemoprevention seems to be promising for reducing cancer incidence both in well-defined high-risk individuals and also in the general population. Based on mechanism of action, two classes of agents – selective oestrogen receptor modulators and retinoids – are effect...

s from “The Sixth Scientific Conference of the Charles University Faculty of Medicine and University Hospital“, 23 January 2002, Hradec Králové ....................................................47

Abbreviations: AD, after-discharge; ADD, AD duration; ADT, AD threshold; PS, primary site; PTE, positive transfer effect; SS, secondary site Kindling is the progression of behavioral and electrographical seizure induced by repeated activation of neural pathways with initial subclinical stimulations (Goddard et al., 1969). Once kindling is established, the kindling effect is sustained for a long...

The effects of estradiol (E2) on urodynamic parameters were studied with twenty 16-month-old female Wistar rats. They were divided into 4 groups, i.e., Group I: untreated; Groups II and III: treated with E2 for 4 and 8 weeks, respectively; Group IV: treated with a placebo for 8 weeks. After treatment, we measured their plasma E2 levels, and recorded their voiding behavior for 24 h. Cystometry w...

3. Parsian H et al. Relationship between serum hyaluronic acid level and stage of liver fibrosis in patients with chronic hepatitis. Biochemia Medica 2009;19(2):154-65. Authors have submitted their work to Biochemia Medica along with a cover letter clearly stating that their manuscript is original, has not been published before and is not currently being considered for publication elsewhere.

D a t a s o u r c e s Studies were identified by searching databases including MEDLINE; EMBASE/ Excerpta Medica; PsycLIT; CINAHL; the Cochrane Library; and the Cochrane Collaboration Depression, Anxiety, and Neurosis Register of Randomized Controlled Trials (RCTs) and controlled clinical trials (for trials completed by April 1998). Search terms included primary health care, counseling, psychoth...

D a t a s o u r c e s Studies published from 1966 to July 1999 were identified by searching the Cochrane Airways Group trials database (derived from MEDLINE, EMBASE/Excerpta Medica, CINAHL; hand searches of 18 relevant journals and proceedings of 3 respiratory societies; and reviews of bibliographies of relevant studies). Pharmaceutical companies that manufacture inhaled asthma drugs were conta...

D a t a s o u r c e s Studies were identified by searching the Cochrane Central Register of Controlled Trials (2003), MEDLINE (1966 to January 2003), EMBASE/Excerpta Medica (1974 to April 2002), and HEALTHLINE (1988 to April 2002); reviewing current trials published before April 2002; searching the reference lists of published studies; handsearching abstracts of congresses; and contacting resea...