Kim, Yuri V., Francescopaolo Di Cello, Coryse S. Hillaire, and Kwang Sik Kim. Differential Ca signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells. Am J Physiol Cell Physiol 286: C31–C42, 2004. First published August 27, 2003; 10.1152/ajpcell.00157. 2003.—Thrombin and related protease-activated receptors 1, 2, 3, and 4 (PAR1–4...

The object of this study is to analyze the factors influencing success of Bank-issued micropayment systems in Iran. Based on an existing IS post acceptance model which considers well known factors, we focus on studying the influence of a new factor related to compulsion (direct and indirect).  Our model consists of seven main factors along with ‘Direct compulsion’ defined as a mediator v...

The capsid of the human polyomavirus JC virus (JCV) consists of 72 pentameric capsomeres of a major structural protein, Vp1. The cysteine residues of the related Vp1 of SV40 are known to contribute to Vp1 folding, pentamer formation, pentamer-pentamer contacts, and capsid stabilization. In light of the presence of a slight structural difference between JCV Vp1 and SV40 counterpart, the way the ...

kappa-Bungarotoxin, a kappa-neurotoxin derived from the venom of the banded Krait, Bungarus multicinctus, is a homodimeric protein composed of subunits of 66 amino acid residues containing five disulfide bonds. kappa-Bungarotoxin is a potent, selective, and slowly reversible antagonist of alpha3 beta2 neuronal nicotinic acetylcholine receptors. kappa-Bungarotoxin is structurally related to the ...

Nitroxyl (HNO), the reduced and protonated form of nitric oxide (NO·), confers unique physiological effects including vasorelaxation and enhanced cardiac contractility. These features have spawned current pharmaceutical development of HNO donors as heart failure therapeutics. HNO interacts with selective redox sensitive cysteines to effect signaling but is also proposed to activate soluble guan...

Serine proteases play an important role in the regulation of most biological processes. Malfunctions in this class of enzyme lead to a variety of diseases and thus are an important target in medicinal chemistry. Trypsin is a digestive proteinase which cleaves peptide bonds at the carboxyl side of lysine or arginine via the conserved catalytic triad (Ser 195, His 57, and Asp 102) which is charac...

This paper discusses conceptual frameworks for measuring the effects of innovation policy and begins with applying conventional descriptive methods to explore how firms rate and rank the merits of public intervention. Based on survey data from some 1200 Austrian firms we then challenge the hypothetical survey question (“What would you have done if public support was denied?”) by comparing the r...

BACKGROUND Serum metabolites are associated cross-sectionally with kidney function in population-based studies. METHODS Using flow injection and liquid chromatography tandem mass spectrometry methods, we examined longitudinal associations of baseline concentrations of 140 metabolites and their 19 460 ratios with kidney function decline and chronic kidney disease (CKD) incidence over 7 years i...

The liver plays a central role in the postpartum (PP) energy metabolism of transition dairy cow; however, studies describing metabolome during this period were lacking. aim presented study was therefore to compare alterations and blood cows. For purpose, an on-farm trial with 80 German Holstein cows (mean lactation number: 3.9; range: 2–9) performed, thorough documentation clinical traits chemi...