We have identified three novel structures for inhibitors of the poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA and implicated in DNA repair, apoptosis, organ dysfunction or necrosis. 2-[4-(5-Methyl-1H-imidazol-4-yl)-piperidin-1-yl]-4,5-dihydro-imidazo[4,5,1-i,j]quinolin-6-one (BYK49187), 2-(4-pyridin-2-yl-phenyl)-4,5-dihydro-imidazo[4,5,1-i,j]quinolin-6-o...

Communication of command and control (C2) information for military forces is moving towards more digitized systems. As such, not only are humans consuming this information but also more and more automated systems are doing so. Most recently there has been a need to use simulations to stimulate and be stimulated by the Command, Control, Communications, Computers, Intelligence, Surveillance and R...

One of the newest initiatives in the evolution of the World Wide Web (WWW) is the specification of standards and technologies to create the Semantic Web. Whereas most of today’s WWW is targeted primarily at human readers, the Semantic Web will support human readers while providing enriched data descriptions to enable software agents to perform automated reasoning, creating a Web of knowledge. I...

Simulation models can be valuable to investigate potential effects of climate change on greenhouse gas emissions from terrestrial ecosystems. DNDC (the DeNitrificationDeComposition model) was tested against observed soil respiration data from adjacent pasture and arable fields in the Irish midlands. The arable field was converted from grassland approximately 50 years ago and managed since 2003 ...

Evaluating the Contribution of Uncertainty Management to a Fusion System Report Title By its very nature, fusion requires managing uncertainty. While uncertainty management is built into many standard low-level fusion algorithms, and the importance of uncertainty management is widely recognized at all levels of the JDL hierarchy, there is less commonality of approaches to uncertainty management...

We have identified three novel structures for inhibitors of thepoly(ADP-ribose) polymerase (PARP), a nuclear enzyme activatedby strand breaks in DNA and implicated in DNA repair, apoptosis,organ dysfunction or necrosis. 2-[4-(5-Methyl-1H-imidazol-4-yl)-piperidin-1-yl]-4,5-dihydro-imidazo[4,5,1-i,j]quinolin-6-one(BYK49187), 2-(4-pyridin-2-yl-phenyl)-4,5-dihydro-imidazo[4,...