Abstract Background: Single nucleotide polymorphisms (SNPs) in some genes which are involving in sperm maturation, are considered as one of the main reason for male infertility. Any changes in protamine genes may cause abnormal histone-protamine replacement during spermiogenesis and have been indicated to cause sperm DNA damage and infertility. Objective: The aim of present case-control study w...

the objective of the present study was to scan the whole genome in sheep for identifying the loci associated with wool diameter. blood samples were collected from 94 animals, consisting 47 samples per each lori-bakhtiary and zel breeds. genotyping of samples were performed using ovine 50k snp chip arrays. quality control filters were applied for the initial genotyping data and 48,056 snps belon...

background: as a dna repair protein, flap endonuclease 1 is a key enzyme in maintaining genomic instability and preventing carcinogenesis. two single nucleotide polymorphisms (snps), -69g>a and 4150g>t are associated with dna damage. this meta-analysis is to evaluate the genetic effects of fen1 gene snps (-69g/a and 4150g/t) and the susceptibility to diseases, including glioma risk, breast canc...

inflammatory bowel disease (ibd) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. assessment of tumor necrosis factor (tnf-α) gene polymorphisms in many populations showed a possible association with ibd. considering the genetic variety in different ethnic groups, the aim of the present study was to inve...

background: the aim of this study was to examine the interaction of dietary food groups and genetic variants of apoa1/apoc3, relative to metabolic syndrome (mets) risk in adults. methods: in this matched nested case-control study, 414 mets subjects and 414 controls were selected from among participants of tehran lipid and glucose study. dietary intake was assessed with the use of a valid and re...

Background: Apolipoprotein A2 (APOA2) is the second major apolipoprotein of the high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails of HDL-C levels and its relationship with HDL-C level. Methods: This cross-sectional survey was conducted on participants from Tehran Glucose and Lipid Study (TLGS) at Research Ins...

the fecundity in sheep has been much interested for producers due to its economical importance. growth differentiation factor 9 (gdf9) is an autosomal gene with over dominance effect for twosingle nucleotide polymorphisms(snps), which resulted in sterility in homozygote mutant ewes and additive effect for three snps, without showing sterility event. in the present study, dna was extracted from ...

objective(s): the enzymatic activity of fungi has recently inspired the scientists with re-explore the fungi as potential biofactories rather than the causing agents of humans and plants infections. in very recent years, fungi are considered as worthy, applicable and available candidates for synthesis of smaller gold, silver and other nano-sized particles.  materials and methods: a standard str...

our previous studies on thalassemia patients, homozygous or compound heterozygous for severe beta thalassemia mutations, has suggested that 5’hs4-lcr and/or xmn1-hbg2 backgrounds, which were linked in our thalassemia patients, are important in determining the blood transfusion dependency of these individuals. while the majority of patients with aa/-- 5’hs4/xmn1 background, were severely depende...