Datura innoxia cells from suspension cultures were selected for their ability to grow and divide rapidly in normally lethal concentrations of cadmium. Cells resistant to 12.5, 25, 50, 100, 160, 200, and 250 micromolar cadmium chloride were isolated and utilized to initiate cell suspension cultures resistant to this toxic metal ion. Variant cell lines retained their ability to grow in cadmium af...

Male Wistar rats were exposed to a water solution of cadmium chloride (labelled with cadmium-109) at a dose corresponding to 10 mg Cd/kg diet for 28 days. Carcass, hepatic, renal and testicle distribution of cadmium was studied for 32 days after dosing. Our results indicate that the carcass deposition of cadmium was at a comparative level during the experimental period. Hepatic distribution pat...

The aim of the study was the evaluation of cadmium effects on the activity of antioxidant enzymes in rat hepatocytes. The studies were conducted with isolated rat hepatocytes incubated for 1 or 2 hours in a modified (deprived of carbonates with phosphates) Williams' E medium (MWE) in the presence of cadmium chloride (25, 50 and 200 microM). Hepatocytes incubated in the MWE medium without cadmiu...

The use of electrodialysis to remove cadmium from water has been shown to be feasible for a wide range of conditions. As much as three orders of magnitude reduction in the concentration of cadmium was observed for the feed with the concentrate stream from the process containing cadmium concentrations greater than 100,OOO ppm. The effect of cadmium concentration, pH, and added sodium chloride co...

Purpose: To investigate the protective role of evodiamine, a naturally occurring anti-inflammatory, antioxidant, and anti-apoptotic compound, against cadmium-induced cytotoxicity in proximal tubular cells (human kidney 2; HK-2).
 Methods: HK-2 were treated with different concentrations evodiamine (5, 20, 50 ?M) for 2 h then incubated 40 ?M cadmium chloride another 24 h. Cell viability apop...

The teratogenicity of cadmium chloride (16 pM/kg Cd++) was studied in Wistar rats from two commercial sources. Subcutaneous cadmium was not teratogenic. Intraperitoneal cadmium was highly teratogenic in both stocks when given on day 9, 10, or 11 of gestation. There were marked differences between the two stocks in fetal mortality and the incidence and types of malformations produced. Cadmium on...

Though our previous study has showed that pretreatment with Orthosiphon Stamineus methanol extract (OSM) prevents gentamycin induced nephrotoxicity. No report has been documented on the effect of Pretreatment of OSM with Cadmium and Lead. Therefore this study aims to investigating the effect of pretreatment with OSM on Cadmium and Lead induced Nephrotoxicity. Nephrotoxicity was induced in Wista...

Antioxidant effect of Herbal product and Synthetic Methionine was evaluated in broilers. Six groups containing 12 birds in each group. Group I served as control fed with basal diet deficient with methionine. Group II served as toxic control fed with cadmium chloride at 100 ppm. Group III and IV served as positive control fed with Methiorep® at 1.4 g/kg diet and synthetic methionine at 1.2 g/kg ...

Salts of divalent cadmium are well-known human mutagens and carcinogens. In the present work, the ability of vitamin C to modulate genotoxic effects of cadmium chloride on human lymphocytes was assessed using single cell gel electrophoresis (comet assay). Vitamin C at 20 and 100 micromol/l and cadmium at 5, 30 and 150 micromol/l significantly increased the tail moment of lymphocytes. Vitamin C ...