نتایج جستجو برای: calcipotriol
تعداد نتایج: 383 فیلتر نتایج به سال:
Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the...
BACKGROUND Psoriasis vulgaris is one of the most common dermatologic diseases in Germany with a prevalence of about 2%. Along with efficacy and safety, costs are an important criterion for selecting appropriate therapy for this chronic disease. The majority of the patients with mild to moderate psoriasis vulgaris can be successfully treated with topical therapy alone. The most important agents ...
Charged sodium channel blockers (CSCBs) such as NTX-2009 do not cross membranes, and selectively inhibit sensory nerves by gaining access to nociceptors through large pore channels (eg TRPV1, TRPA1) that are open due inflammation. Evidence suggests transmit itch pain signals the CNS play an important role in driving immune response psoriasis atopic dermatitis. We examined whether blockade of sk...
of the hair follicles) and differentiates it from the other conditions.5 Histology of tissue obtained by curettage of a papule is sufficient to establish the definitive diagnosis. Although there are reports of GP that resolved spontaneously once the irritant was eliminated, the lesions usually persist. A number of therapeutic modalities, including topical and oral preparations of retinoids, vit...
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