نتایج جستجو برای: calcitonin gene
تعداد نتایج: 1144069 فیلتر نتایج به سال:
Earlier studies of the methylation status of total genomic DNA and of specific genes have demonstrated, predominantly, hypomethylation in human neoplasms. However, we have recently documented the presence of new sites of methylation in the calcitonin gene in human lymphomas (100%), small cell lung carcinomas (92%), and acute myeloid leukemias (95%). We now report that these same novel calcitoni...
Historical perspectives In this issue of the JCI, the elegant publication by Hoff and colleagues (1), by serendipity or on purpose, falls on the 40th anniversary of the discovery of calcitonin (CT) as a hypocalcemic principle from the parathyroid gland (2). The parathyroid origin of calcitonin was revisited shortly thereafter, and a thyroid C cell origin was firmly established (3, 4). Calcitoni...
Calcitonin gene-related peptide, a potent vasodilator neuropeptide, is localized in perivascular sensory nerves. We have reported that alpha-calcitonin gene-related peptide knockout mice have elevated baseline blood pressure and enhanced hypertension-induced renal damage compared with wild-type controls. Thus, the aim of this study was to determine the mechanism and functional significance of t...
BACKGROUND AND PURPOSE Calcitonin gene-related peptide is an endogenous vasodilating neuropeptide with a dense concentration in the trigeminocerebrovascular system. It is hypothesized that depletion of this peptide contributes to delayed cerebral ischemia after subarachnoid hemorrhage and that an exogenous supply of calcitonin gene-related peptide will augment ischemic cerebral blood flow and r...
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