In a rural community, where low calcium intakes and a high prevalence of hypocalcemia elevated alkaline phosphatase values and hypocalciuria had previously been documented, two groups of 30 black school children were supplemented with calcium (500 mg/day) or a placebo for a period of 3 months. No change in serum calcium or alkaline phosphatase values occurred in the placebo group, while a signi...

CONTEXT Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. OBJECTIVE The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. DESIGN The study was a double-blind, placebo-controlled, ran...

Calcium and phosphorus exist in a delicate balance in the body, with bone playing a central role in maintaining whole-body calcium–phosphorus homeostasis. The balance of phosphorus and calcium in healthy individuals is maintained through the complex interplay between parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 (calcitriol). If serum calcium levels fall, PTH acts to increase renal rea...

Background Vitamin D deficiency is associated with physiologic changes that are similar to pathogenesis of preeclampsia. Although association of vitamin D and preeclampsia has been studied previously, their results are not consistent. The aim of this study was to investigate the relationship of serum vitamin D and calcium with preeclampsia severity. Materials and Methods: This case- control st...

Osteoporosis (OP) has been a global health concern, and calcium supplements are still an effective method to relieve the disease. In this study, we investigated pharmaceutical properties, antiosteoporosis, adverse effects of novel supplement named compound carbonate granule (CCCG). The dissolution rate, stability vitamin D3, drug permeability were explored. And osteoporosis was constructed in m...

OBJECTIVE To evaluate the efficacy of a combined calcium and vitamin D (Ca-D3) supplement for vitamin D deficiency in a small group of postmenopausal women. METHODS A prospective open label 3 month-study. PARTICIPANTS 23 postmenopausal women (mean age 61.2 yrs) with vitamin D deficiency were given a combined oral Ca-D3 supplement called "Osteoblast". The supplement comprises 500 mg elementa...

In another comparison of the same kind, however, three out of thirteen females have broken down in or after early reproduction and with the development of a nervous condition suggestive of relative calcium deficiency. Autopsies of two of them showed no major infections while chemical analysis of the third showed only 0.68 per cent of body calcium upon death at 169 days as compared with averages...

A five and a half year follow up of a girl with end organ resistant rickets is described. After failing to respond to high dose oral alfacalcidol (4 micrograms/kg/day) and calcium supplements, treatment for one year with domiciliary intra-atrial calcium infusions at 2 years of age induced a complete remission, which was maintained on subsequent high dose oral calcium supplement. Overnight infus...