There is wide variation in how patients respond to therapeutics. Factors that contribute to pharmacokinetic variations include disease, genetics, drugs, age, and diet. The purpose of this study was to determine the effect of calorie restriction on the expression of Abcb1a in the intestine and whether calorie restriction can alter the absorption of an Abcb1a substrate (i.e., digoxin) in mice. Te...

OBJECTIVE Increased consumption of sugar-sweetened beverages has contributed to rising obesity levels. Under Canadian law, calories for pre-packaged foods and beverages are presented by serving size; however, serving sizes differ across products and even for the same product in different containers. This study examined consumer understanding of calorie amounts for government nutrition labels an...

Dietary restriction (DR) extends life span in diverse organisms, including mammals, and common mechanisms may be at work. DR is often known as calorie restriction, because it has been suggested that reduction of calories, rather than of particular nutrients in the diet, mediates extension of life span in rodents. We here demonstrate that extension of life span by DR in Drosophila is not attribu...

Computer vision has been introduced to estimate calories from food images. But current food image datasets dont contain volume and mass records of foods, which leads to an incomplete calorie estimation. In this paper, we present a novel food image dataset with volume and mass records of foods, and a deep learning method for food detection, to make a complete calorie estimation. Our dataset incl...

BACKGROUND Depression is a foremost cause of morbidity throughout the world and the prevalence of depression in women is about twice as high as men. Additionally, overweight and obesity are major global health concerns. We explored the relationship between depression and body fat, and the role of physical activity and diet as mediators of this relationship in a sample of 456 adult female Mexica...

Calorie restriction (CR), or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. "Low" can be defined relative to the subject's previous intake before intentionally restricting calories, or relative to an average person of similar body type. Calorie restriction without malnutrition has...

Background and aims: It is well known that dyslipidemia is related to cardiovascular disease, dietary aspect and obesity play an important role in CVD risk factor. In the present study, we investigated the relationship between calorie intake, anthropometrical parameters and serum lipids in apparently healthy women. Methods: The subject were 90 healthy wom...

This paper proposes a finite mixture model (FMM) to model the behavioral transition of calorie consumption with an assumption that nutrition consumption is a mixture of two different behavioral stages: a poor stage and an affluent stage. Based on 387 calorie-income elasticities collected from 90 primary studies, our results identify that the threshold income for calorie demand transition is 459...

Introduction University College London Hospital (UCLH) was one of the largest contributors to the CALORIES trial; a pragmatic, multi-centre, randomised control trial examining the effectiveness of early nutritional support in critically ill patients through a comparison of parenteral and enteral nutrition. The trial found no significant difference in 30-day mortality associated with the route o...

Calorie restriction has been regarded as the only experimental regimen that can effectively lengthen lifespan in various animal models, but the actual mechanism remains controversial. The gut microbiota has been shown to have a pivotal role in host health, and its structure is mostly shaped by diet. Here we show that life-long calorie restriction on both high-fat or low-fat diet, but not volunt...