Fetal rat calvaria were incubated in Krebs-Ringer-bicarbonate medium, containing glucose (2 mg per ml) and bovine serum albumin (1 mg per ml). Incubation in a medium with 0.3 or 0.6 mM dibutyryl adenosine 3’,5’monophosphate (DBcAMP) for 15 min caused a Zto S-fold increase in the tissue concentration of adenosine 3’,5’monophosphate (3’,5’-AMP). This rise could not be explained by degradation of ...

Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) mRNAs we...

The recent identification of the genes responsible for several human genetic diseases affecting bone homeostasis and the characterization of mouse models for these diseases indicated that canonical Wnt signaling plays a critical role in the control of bone mass. Here, we report that the osteoblast-specific transcription factor Osterix (Osx), which is required for osteoblast differentiation, inh...

PURPOSE Guided bone regeneration (GBR) is the most widely used technique to regenerate and augment bones. Even though augmented bones (ABs) have been examined histologically in many studies, few studies have been conducted to examine the biological potential of these bones and the healing dynamics following their use. Moreover, whether the bone obtained from the GBR procedure possesses the same...

The fossil calvaria known as the Mojokerto child's skull was discovered in 1936, but uncertainties have persisted about its paleoenvironmental context and geological age because of difficulties in relocating the discovery site. Past relocation efforts were hindered by inaccuracies in old base maps, intensive post-1930s agricultural terracing, and new tree and brush growth. Fortunately geologic ...

Mycoplasmas may be associated with rheumatoid arthritis in various animal hosts. In humans, mycoplasma arthritis has been recorded in association with hypogammaglobulinemia. Mycoplasma fermentans is one mycoplasma species considered to be involved in causing arthritis. To clarify which mycoplasmal compounds contribute to the inflammatory, bone-destructive processes in arthritis, we used a well-...

BACKGROUND Recent studies have shown that lactoferrin promotes the proliferation and differentiation of osteoblasts and inhibits osteoclast-mediated bone resorption. Anorganic bovine bone (ABB) graft has been extensively used as an osteoconductive material in the bone reconstructive surgeries. The purpose of this study was to examine whether the combination of lactoferrin with Bio-Oss would imp...

Suday, O cber 8, 2017 CONCLUSION: Open cranial vault remodeling with fronto-orbital advancement is a safe and reproducible procedure with excellent literature to support short-term outcomes. However, little data exist to evaluate this patient population as they mature. Our study critically evaluates physical exam findings, neurocognitive development, and anthropometric assessments in this patie...

The effect of bradykinin on bone resorption was studied in cultures of newbornmouse calvaria. Bradykinin (0.03,UM, 1 Mm) stimulated the release of 4'Ca2+ from bones dissected out from mice prelabelled in vivo with 45Ca. Bradykinin (1 Mm) also augmented the release of stable calcium (4"Ca), Pi and the lysosomal enzyme f,glucuronidase. The stimulatory effect of bradykinin on mineral mobilization ...

1. Foetal rat hemi-calvaria were incubated in organ culture with sera from patients with active rheumatoid arthritis. 2. Increased 45Ca resorption was produced by sera from patients who were hypercalcaemic. 3. This bone-resorbing effect could be inhibited by calcitonin.