The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life cycle, and antiviral agents that target the core protein are being developed. Capsid assembly modulators (CAMs) are compounds that target core and misdirect capsid assembly, resulting in the suppression of HBV replication and virion production. Besides HBV DNA, circulating HBV RNA has been detected in...

Cell adhesion molecules (CAMs) mediate cell attachment and stress transfer through extracellular domains. Here we forcibly unfold the Ig domains of a prototypical Ig superfamily CAM that contains intradomain disulfide bonds. The Ig domains of all such CAMs have conformations homologous to cadherin extracellular domains, titin Ig-type domains, and fibronectin type-III (FNIII) domains. Atomic for...

Content addressable memories (CAMs) have significantly lower capacities than RAMs. Following a summary of large-capacity CAM applications and a brief tutorial look at CAM operation, this paper reviews the sources of this capacity disadvantage: comparator area overhead and difficulty implementing two-dimensional decoding. Past attempts at achieving higher CAM density and capacity are reviewed, a...

Abstract. Biogenic volatile organic compounds (BVOCs) emitted from the terrestrial vegetation into Earth's atmosphere play an important role in atmospheric chemical processes. Gridded information of their temporal and spatial distribution is therefore needed for proper representation composition by air quality models. Here we present three newly developed high-resolution global emission invento...

Surface coating is a crucial method to mitigate the aging problem of high-Ni cathode active materials (CAMs). By avoiding direct contact CAM and electrolyte, side reactions are hindered. Commonly used techniques like wet or ALD time consuming costly. Therefore, more cost-effective technique desirable. Herein, facile fast dry powder process for CAMs with nanostructured fumed metal oxides reporte...

A counterintuitive idea is making the rounds in cancer research: Stickiness promotes mobility. Proteins that help cells stick together, called cellular adhesion molecules (CAMs), may be a driving force in metastasis, and they seem to be present in almost every cancer tested. The good news is that blocking CAMs seems to slow the spread of cancer. In fact, using antibodies to interfere with CAMs ...

Content addressable memories (CAMs) are gaining popularity with computer networks. Testing costs of CAMs are extremely high owing to their unique configuration. In this paper, we carried out a transistor-level fault analysis and devise a search path test algorithm. The proposed algorithm is of the order (nl / log2n) compared to the brute-force algorithm of complexity (nl). For the analyzed CAM,...

background patient’s rights are worldwide considerations. saudi patient’s bill of rights (pbr) which was established in 2006 contained 12 items. lack of knowledge regarding the saudi pbr limits its implementation in health facilities. this study aimed to investigate the knowledge of health professions’ students at college of applied medical sciences (cams) riyadh saudi arabia regarding the exis...

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 7197 wileyonlinelibrary.com Circumstance-adaptive materials (CAMs) are those that can change their properties—mechanical, optical, electrical, magnetic, biological, and so on—to respond to their use or environment; [ 3–8 ] they represent a current challenge in materials science. Among the wide variety of possible CAMs, we focus on materials whos...

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are released from neurons in an activity dependent manner. Published studies suggest their activity is important to varied forms of learning and memory. At least one MMP can stimulate an increase in the size of dendritic spines, structures which represent the post synaptic component for a large number of glutamatergic synap...