The incidence of second malignant neoplasms (SMNs) was investigated among 1,988 patients with complete data, enrolled in the SIOP Wilms tumor trials and studies 1, 2, 5, and 6, treated between September 1971 and October 1987. By the end of 1992, eight SMNs were documented, whereas only 1.3 were expected (standardized incidence ratio [SIR] = 4.15; 95% CI = 1.79, 8.17). The risk increases in the ...

BACKGROUND With over 13 million cancer survivors in the United States today, second cancers are of rapidly growing importance. However, data on nontreatment risk factors for second cancers are sparse. We explored the feasibility of pooling data from cohort studies of cancer incidence to investigate second cancer etiology. METHODS We combined data from five prospective studies including more t...

PURPOSE/OBJECTIVES To provide a systematic review of the secondary prevention practices of cancer survivors guided by the Interaction Model of Client Health Behavior. DATA SOURCES Articles published in peer-reviewed journals from 1996-2007. DATA SYNTHESIS Despite their increased risk for second cancers, few cancer survivors maintain regular follow-up with a clinician knowledgeable of late e...

Second primary malignancy following multiple myeloma (MM) was reported several years ago. There are also rare reports of cases with synchronous MM and other malignancies. To our knowledge, only one case of MM following bladder cancer has been reported in the literature. Here, we report the second case occurred three months after diagnosis of bladder cancer.

PURPOSE Screening for second primary cancer (SPC) is one of the key components to survivorship care. We aim to evaluate the oncologists' experience with SPCs and assess the current practice, perceived barriers, and recommendations related to SPC screening. MATERIALS AND METHODS A nationwide survey was conducted with a representative sample of 496 Korean oncologists. A questionnaire based on t...

Radiotherapy has always involved the unavoidable irradiation of organs and tissues outside the target volume. Consequently, delivery of the prescribed target dose whilst minimizing the dose to surrounding critical organs is a key objective of treatment planning. One of the detrimental effects of unwanted irradiation of critical organs is the probability of induction of a second cancer. This com...

It may be useful to look at the risk patterns for developing a second primary malignancy after a first primary melanoma diagnosis in order to understand the etiology and mortality due to melanoma. In this volume, W.B. Grant has proposed the interesting hypothesis that solar UV radiation and smoking may be inversely associated with the development of melanoma through the presence of dermal or so...

Colorectal cancer is one of the most common malignancy in the world and the second cancer-related death, many molecular and genetic aspects of this disease have been cleared as chromosomal instability and the role of some key proteins as WNT/β catenin, trypsin and others. Also recently the role of folate turnover and some neurotransmitters as serotonin were also considered. The scope of this re...

Significant advances in the detection and treatment of initial cancers increase likelihood life-threatening subsequent primary cancers, particularly for long-term survivors. A brief patient case regarding a Hodgkin lymphoma survivor with gastric cancer will demonstrate how care providers can identify potential using American Cancer Society website. Primary have an essential role recognizing cri...

Background: Skin cancers are the most prevalent type among the white with an increasing trend of incidence around the world and Iran. Scientific developments in diagnosing these cancers and using screening methods and utilizing treatment methods have contributed to the relative control of the cancer. Hence, it is necessary to consider other suggested approaches of complementary and traditional ...