The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2alpha (eIF2alpha) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells makes it an attractive molecular target in need of further characterization. In this work, we have cloned and expressed the canine form of t...

Epidemiological research of canine cancers could inform comparative studies of environmental determinants for a number of human cancers. However, such an approach is currently limited because canine cancer data sources are still few in number and often incomplete. Incompleteness is typically due to under-ascertainment of canine cancers. A main reason for this is because dog owners commonly do n...

BACKGROUND Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs. RESULTS We found a high occurrence of copy number aberrations in canine mammary tumours, lo...

BACKGROUND AND AIM: Tooth extraction as a part of orthodontic treatment plan to create space for leveling and aligning teeth or causing tooth movement leads to changes in arch width and length. The outcome of these changes is important for the clinicians and affects the treatment and retention plans. Despite some previous studies, data in this regard are still scarce and further investigation i...

INTRODUCTION Degeneration of the intervertebral disc (IVD) is a frequent cause for back pain in humans and dogs. Link-N stabilizes proteoglycan aggregates in cartilaginous tissues and exerts growth factor-like effects. The human variant of Link-N facilitates IVD regeneration in several species in vitro by inducing Smad1 signaling, but it is not clear whether this is species specific. Dogs with ...

2 Veterinary Student Platform Presentation Canine PBMC NSG mice: A model of canine specific immunity to allogeneic canine mammary tumor-DC fusion vaccines Jeremy Foote Ph.D., Patricia Deinnocentes, Farruk M.L. Kabir, Bruce Smith Ph.D., VMD and Richard Bird Ph.D. Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL Introduction. Invasive breast cancer is the most fre...

Mutations in canine superoxide dismutase 1 (SOD1) have recently been shown to cause canine degenerative myelopathy, a disabling neurodegenerative disorder affecting specific breeds of dogs characterized by progressive motor neuron loss and paralysis until death, or more common, euthanasia. This discovery makes canine degenerative myelopathy the first and only naturally occurring non-human model...

Within 3 hours of induction of acute hydrocephalus in a canine model, lateral ventricular CSF pressure increased from an initial average of 14.6 +/- 2.8 cm H2O to 40.2 +/- 5.7 cm H2O. Ventricular volumes, as measured from MR images, increased 1.45 +/- 0.94 cm3, 1.92 +/- 0.82 cm3, and 2.24 +/- 0.60 cm3 after 6, 24, and 48 hours, of hydrocephalus, respectively. This canine model was reliable and ...

Canine ehrlichiosis has emerged as one of the most clinically important tick-borne diseases affecting dogs. Eighty-five naturally infected dogs have been investigated, the most consistent clinical signs recorded were fever, emaciation and lymphoadenopathy, anemia, monocytosis, thrompocytopenia, hypoalbuminemia, elevation in liver enzymes and total bilirubin were the most remarkable changes asso...