The aim of our study was to evaluate the effects cannabinoids and serotonergic system on nociception in intact rats after heat stress. Cannabinoid receptor type 1 (CB1) 5-hydroxytryptamine (5НТ 1А ) agonists antagonists have been administered according different experimental designs (alone combinations) male Wistar rats, as well animals subjected one hour Pain perception has evaluated by Paw pr...

inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. cannabinoids inhibit neuroinflammation and the immune cells express the whole machine...

Cannabinoids, such as marijuana, are known to impair learning and memory perhaps through their actions in the hippocampus where cannabinoid receptors are expressed at high density. Although cannabinoid receptor activation decreases glutamatergic synaptic transmission in cultured hippocampal neurons, the mechanisms of this action are not known. Cannabinoid receptor activation also inhibits calci...

“Cannabinoid” is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact mostly at the level of the currently recognized cannabinoid receptors, they might have cross reactivity, such as at opioid receptors. Patients with malignant disease represent a cohort within health...

The CB(1) and CB(2) cannabinoid receptors are G protein-coupled receptors (GPCRs) recognized by a variety of endogenous ligands and activating multiple signalling pathways. This multiplicity of ligands and intracellular transduction mechanisms supports a complex control of physiological functions by the endocannabinoid system, but requires a finely tuned regulation of the signalling events trig...

Some of the most compelling evidence supporting an association between cannabinoid agonists and psychosis comes from controlled laboratory studies in humans. Randomized, double-blind, placebo-controlled, crossover laboratory studies demonstrate that cannabinoid agonists, including phytocannabinoids and synthetic cannabinoids, produce a wide range of positive, negative, and cognitive symptoms an...

BACKGROUND While cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown. METHODOLOGY/PRINCIPAL FINDINGS The activity of the endocannabinoid system was evaluated in human chronic pancreatitis (CP) tissues. In vitro, effects of blockade and activation of cannabinoid receptors on pancreatic stellate cell...

Obesity and metabolic syndrome, along with drug dependence (nicotine, alcohol, opiates), are two of the major therapeutic applications for CB(1) cannabinoid receptor antagonists and inverse agonists. In the present study, we report the synthesis and structure-affinity relationships of 1,5-diphenylimidazolidine-2,4-dione and 1,3,5-triphenylimidazolidine-2,4-dione derivatives. These new 1,3,5-tri...

Abstract: Cortical long-term depression (LTD) and long-term potentiation (LTP) are thought to be important mechanisms for the plasticity of topographic sensory maps, especially in rodent somatosensory (barrel) cortex. At the layer (L) 4 to L2/3 synapse in rat barrel cortex, LTP and LTD can be induced by spike timing-dependent plasticity (STDP) in which the precise, millisecond-scale timing of p...

BACKGROUND AND PURPOSE Opioids and cannabinoids interact in drug addiction and relapse. We investigated the effect of the opioid receptor antagonist naloxone and/or the cannabinoid CB(1) receptor antagonist rimonabant on cannabinoid-induced reinstatement of heroin seeking and on cannabinoid substitution in heroin-abstinent rats. EXPERIMENTAL APPROACH Rats were trained to self-administer heroin ...