Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)–expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19–CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngen...

Car-sharing systems have become a promising research direction due to the development of the Internet. Previous research mainly focus on how to pick more passengers up, which ignores whether the real income of car-drivers is increasing. In this paper, we exploit a model for car-sharing system named “MCSS”, which can make precise prediction on whether a passenger should be picked up while in an ...

This research effort analyzes the Wiedemann car-following model using car-following periods that occur at different speeds. The Wiedemann car-following model uses thresholds to define the different regimes in car following. Some of these thresholds use a speed parameter, but others rely solely upon the difference in speed between the subject vehicle and the lead vehicle. The results show that t...

A numerical model based on Lagrange-D’Alembert principle is proposed for car-to-car end impact in this paper. In the numerical model, the friction forces are treated by using local linearization model when solving the differential equations. A computer program has been developed for the numerical model based on Runge-Kutta fourth-order method. The results are compared with the Multibody Dynamic...

This paper deals with two modeling approaches to car driving. The first one is a system theoretic approach to describe adaptive human driving behavior. The second approach utilizes neural networks. As an illustrative example the overtaking task is considered and modeled in system theoretic terms. Model results are used to teach a neural network. The results show that a neural network is able to...

Semi-active Fuzzy control of quarter car system having three degrees of freedom and assembled with magnetorheological (MR) shock absorber is studied in present paper. First, experimental work was performed on an MR shock absorber under different excitation conditions to obtain force-displacement and force-velocity curves. Then, for the application of experimental data in semi-active quarter car...

Driver behavior plays an important role in modeling vehicle dynamics in a traffic simulation environment. To study one element of the general driver behavior, that of car following, an advanced instrumented vehicle has been applied in dynamic data collection in real traffic flow on Swedish roads. This paper briefly introduces our car following data collection and smoothing methods. Moreover, we...

Chimeric-antigen-receptor (CAR) T cells targeting CD19 show dramatic remissions in refractory or relapsed acute lymphoblastic leukemia. Interleukin-6 (IL-6) has been associated with severe cytokine release syndrome (CRS) following CAR T cell treatment, leading to significant toxicity and death. CRS could be treated with an antiIL6-receptor antibody, with reversal of most of the inflammatory res...

This paper aims at exploring the use of sentiment analysis on social media as a tool for sales forecasting in the automotive industry. Previous research on this topic has presented significant results although current literature still lacks investigation on the usefulness of this technique when it comes to more expensive items. In particular, about 500,000 social media posts and eleven car mode...