Carbamazepine is frequently administrated to alcohol addict patients. The aim of this study was to evaluate the influence of alcohol addiction on carbamazepine pharmacokinetics and severity of drug intoxication. The total of 158 carbamazepine intoxicated patients participated in the study (76 non-alcohol-dependent, and 82 alcohol-dependent subjects). The results of the study indicate that the l...

Keynote address: " Marfan syndrome and related disorders: from gene to therapy " Prof. 3 AED Pregnancy register, UK and Ireland Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The risk magnitude varies by AED exposure. We provide results from the UK and Ireland Epilepsy and Pregnancy Registers, of the risk of MCMs after monotherapy...

normal 0 false false false en-us x-none ar-sa background: carbamazepine has been used as aeds since 1965, and is most effective against partial seizures. two basic mechanisms of action have been proposed: 1) enhancement of sodium channel inactivation by reducing high-frequency repetitive firing of action potentials, 2) and action on synaptic transmission. the aim of this study was to provide a ...

There is a current concern, among the scientific community, on pollutants classified as “persistent organic (POPs)”. Pharmaceuticals and personal care products (PPCPs) belong to this family of contaminants; therefore, it necessary find more efficient techniques able achieve their removal from environment. This study focuses two different pharmaceuticals: carbamazepine atenolol, chosen for wides...

Plasma sodium and osmolality were determined in 80 adult epileptic patients receiving chronic treatment with carbamazepine and in 50 control patients treated with other anticonvulsant drugs. Mean plasma osmolality was significantly lower in the carbamazepine-treated patients but mean plasma sodium did not differ in the two groups. Hyponatraemia was found in five of the carbamazine-treated patie...

Serious complications after carbamazepine poisoning, such as coma, seizures, respiratory failure, cardiac conduction abnormalities, and death are more likely with serum levels greater than 170 micromol L(-1). We report a case of a single massive carbamazepine overdose in a 19-year-old male, following attempted suicide, without prior history of seizure disorder. On admission, three hours after i...

The study was carried out in rabbits, to see the effect of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1⁄2a. t 1/2e. AUCo-α of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine also reduced significantly in comparison to those of control rabbits after 7 days coadministration of ...

The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-adminis...

In the present work, treatment of a mixture six emerging pollutants (acetamiprid, acetaminophen, caffeine, amoxicillin, clofibric acid and carbamazepine) by means photo-Fenton process has been studied, using simulated sunlight as an irradiation source. Removal these investigated in three different aqueous matrices distinguished amount chlorides (distilled water, 1 g L?1 NaCl 30 NaCl) at pH 2.8 ...

Carbamazepine is widely used for the treatment of epilepsy, trigeminal neuralgia and psychiatric disorders. However, therapy often ineffective, some patients experience adverse drug reactions, which negatively affect both efficacy safety therapy.
 This review systematized presented up-to-date information regarding pharmacokinetics pharmacogenetics carbamazepine, as well most common reactio...