I read with interest the EHP supplement on oxygen radicals and lung injury (vol. 102, supplement 10). I would like to take this opportunity to comment about this supplement and raise a key issue concerning the major concepts regarding the mechanisms of cellular injury in inflammatory diseases. As an active investigator in this field of research, I cannot fully understand why there was no mentio...

Cancer is a disease which has long been shrouded in mystery, but our knowledge of its intricacies has been extended in numerous directions by investigations carried on in all parts of the world by workers in many branches of science. Yet it remains true that in general we are not able to explain the origin of cancer, and the methods of treatment at present available are pitifully inadequate. Th...

Important information regarding the reactions of carcinogenic and related hydrocarbons has been obtained chiefly from the following four previous lines of investigation : ( a ) The extensive study of methods of synthesis of carcinogenic hydrocarbons by the technics of the organic chemist (4). ( b ) The experimental study of the oxidative and coupling reactions of such hydrocarbons under conditi...

The current investigation aimed to examine the present status of pollution in Bhima River using indices (degree contamination, heavy metal evaluation index, & index) and health risk assessment (non-carcinogenic carcinogenic) by choosing some metals like copper (Cu), chromium (Cr), manganese (Mn), cadmium (Cd), nickel (Ni), lead (Pb), zinc (Zn). Eight samples surface water were collected mon...

polynuclear Aromatic Bydromrbons As criteria for the presence of polynuclear aromatic hydrocarbons in tobacco smoke, the list of J. W. Cook (m) has been widely accepted by tobacco chemists. The Surgeon General’s 1964 Report and Cook’s paper are in agreement with respect to the presence of benzo(a)pyrene (3 : 4benzopyrene) , dibenz (a,h) -anthracene (12 : 5,6-dibenzanthrac) : benzo(c) phenanthre...

The carcinogenicity of 23 phenylenediamines and related compounds was reviewed. An extensive analysis of the methods used indicated that the bioassays were conducted well. The data suggest that the carcinogenicity of 4-substituted 1,3-phenylenediamines is reduced substantially or eliminated completely by oxidation of one or both amine groups or by N-substitution. Oxidation of a methyl substitue...

Eighty-two soil samples were collected, and As, Pb, Cd, Zn, Cu and Ni were analysed for their concentrations, potential ecological risks and human health risks. The average concentrations of As, Pb, Cd and Zn exceeded their corresponding limits prescribed by the Chinese National Soil Environmental Quality Standard III, while Cu and Ni were far less than prescribed. The potential ecological risk...

In the study of cancer one of the central problems is the elucidation of the pathogenesis of malignant tumors. The direction taken by such studies varies in accordance with prevailing points of view on the etiology of cancer. Since the discovery of carcinogenic compounds by Cook, Kennaway, and others ( i , 7), the theory of a chemical etiology of malignant tumors has been advanced. According to...

Animal models have been used for a number of purposes in metal carcinogenesis studies: (a) to detect carcinogenic activity; (b) to estimate carcinogenic risk; and (c) to investigate mechanisms of metal carcinogenesis. The design of animal tests will be determined by the purpose of the study. In this section we shall distinguish between tests in animals designed to identify carcinogenic activity...