BACKGROUND Myocarditis is an important cause for cardiac failure, especially in younger patients, followed by the development of cardiac dysfunction and death. The present study investigated whether gene deletion of matrix metalloproteinase-2 influences cardiac inflammation and function in murine coxsackievirus B3 (CVB3)-induced myocarditis. METHODS AND RESULTS Matrix metalloproteinase-2 knoc...

Background The pathophysiology of heart failure with normal EF (HFNEF) is still under discussion. Here we study the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. Methods and Results We investigated the left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter and echocardiography...

BACKGROUND The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. METHODS AND RESULTS We investigated left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter method...

Cardiac arrest is a leading cause of death worldwide. While survival rates following sudden cardiac arrest remain relatively low, recent advancements in patient care have begun to increase the proportion of individuals who survive cardiac arrest. However, many of these individuals subsequently develop physiological and psychiatric conditions that likely result from ongoing neuroinflammation and...