Heart rhythm disturbances are being increasingly recognized during the postoperative period. While many are transient and short lived without altering the recovery phase after cardiac or non-cardiac surgery, they do have the potential to pose a threat to patient’s health, prolong hospital stay, and in a minority of patients may even cause death. Continuous monitoring is becoming the standard of...

Alternans is an abnormal cardiac rhythm in which action potential duration alternates from beat-to-beat. In order for an implanted pacemaker to successfully seize control of the heart rhythm, its electrical stimuli have to be carefully timed relative to the firing of the heart’s specialized pacemaker cells. In this manuscript, we use mathematical techniques to analyze a novel feedback control a...

Unravelling the mechanisms controlling cardiac automatism is critical to our comprehension of heart development and cardiac physiopathology. Despite the extensive characterization of the ionic currents at work in cardiac pacemakers, the precise mechanisms initiating spontaneous rhythmic activity and, particularly, those responsible for the specific control of the pacemaker frequency are still m...

BACKGROUND Some previous reports have indicated beneficial cardiac effects of nasal continuous positive airway pressure (NCPAP) in patients with severe congestive heart failure (CHF), but others have reported deleterious cardiac effects, particularly among patients in atrial fibrillation (AF). The aim of this study was to determine if differences in cardiac rhythm influence the acute cardiac re...

Normal heart function requires generation of a regular rhythm by sinoatrial pacemaker cells and the alteration of this spontaneous heart rate by the autonomic input to match physiological demand. However, the molecular mechanisms that ensure consistent periodicity of cardiac contractions and fine tuning of this process by autonomic system are not completely understood. Here we examined the cont...

Background—Some previous reports have indicated beneficial cardiac eVects of nasal continuous positive airway pressure (NCPAP) in patients with severe congestive heart failure (CHF), but others have reported deleterious cardiac eVects, particularly among patients in atrial fibrillation (AF). The aim of this study was to determine if diVerences in cardiac rhythm influence the acute cardiac respo...