The genetic mucopolysaccharidosis syndromes (MPS) are autosomal recessive inborn errors of metabolism. Heart valve involvement in MPS is not uncommon but only a few case reports of successful cardiac surgery are available. In particular, reports of combined aortic and mitral stenosis associated with MPS type I-S are very rare. Both type I and type VI MPS are associated with significant left sid...

We tested the hypotheses that Doppler echocardiography has a higher accuracy than clinical evaluation in the detection of significant aortic and mitral valvular heart disease and that Doppler echocardiography is highly accurate as compared with cardiac catheterization for the assessment of valvular disease severity. Thus, cardiac catheterization for the assessment of valve lesion severity may b...

background and aims: ankylosing spondylitis (as) is an idiopathic chronic inflammatory disease mainly involves sacroiliac and axial joints; but it may also have extra-articular involvement. accordingly, this study was designed to determine the frequency of cardiac involvement among patients with ankylosing spondylitis. methods: this study was performed as a descriptive-analytical cross-section...

conclusions surgical repair of the congenital mv disease yields acceptable early and intermediate-term satisfactory valve function and good survival at intermediate-term follow-up. strong predictors for poor surgical outcome and death were age smaller than 1 year, weight smaller or equal than 6 kg, and associated cardiac anomalies such as pulmonary stenosis. objectives the aim of this study was...

We tested the hypotheses that Doppler echocardiography has a higher accuracy than clinical evaluation in the detection of significant aortic and mitral valvular heart disease and that Doppler echocardiography is highly accurate as compared with cardiac catheterization for the assessment of valvular disease severity. Thus, cardiac catheterization for the assessment of valve lesion severity may b...

BACKGROUND Reoperative cardiac valve surgery via sternotomy is associated with a substantial morbidity and mortality. This study evaluated the right anterolateral thoracotomy for high-risk patients undergoing mitral and tricuspid valve redo procedures. METHODS Out of a series of 173 patients undergoing redo cardiac valve surgery, 24 patients were reoperative via the right anterolateral thorac...

In fetal valve maturation the mechanisms by which the relatively homogeneous proteoglycan-rich extracellular matrix (ECM) of endocardial cushions is replaced by a specialized and stratified ECM found in mature valves are not understood. Therefore, we reasoned that uncovering proteases critical for 'remodeling' the proteoglycan rich (extracellular matrix) ECM may elucidate novel mechanisms of va...

Their cardiac surgical expertise is reflected in extensive sections on native and prosthetic valve assessment as well as transcatheter aortic valve replacement, inter-atrial septum occlusion, ventricular assist devices and cardiac masses. The book is well suited for someone learning or performing TOE in a tertiary centre or referring patients to such a centre for cardiac valvular or device inte...

REPLACEMENT of nonfunctioning valves is a significant recent advancement in the correction of cardiac valvular disease. The most widely used artificial device replacing the mitral valve is the Starr-Edwards ballvalve prosthesis.' Its effectiveness was shown in recent reports by the marked clinical improvement in properly selected patients.2 However, cardiologists and cardiac surgeons are faced ...

Bicuspid aortic valve disease is the most common congenital cardiac anomaly. The prevalence in the general population is between 0.46% and 1.37%. There is significantly high cardiac morbidity associated with bicuspid aortic valve disease, predominantly due to progressive valve dysfunction (stenosis or regurgitation) that requires surgical intervention for symptom relief or prevention of left ve...