Placental insufficiency, resulting in restriction of fetal substrate supply, is a major cause of intrauterine growth restriction (IUGR) and increased neonatal morbidity. Fetal adaptations to placental restriction maintain the growth of key organs, including the heart, but the impact of these adaptations on individual cardiomyocytes is unknown. Placental and hence fetal growth restriction was in...

Cardiomyocytes are terminally differentiated cells characterized as withdrawal cell-cycle machinery, but nonetheless they are known to express cell-cycle regulators. Because many proteins related to the cell cycle induce apoptosis in proliferating cells, we examined the involvement of these proteins in the apoptosis pathway in cardiomyocytes. Primary rat cardiomyocytes were exposed to a severe ...

BACKGROUND Prolonged survival of xenografted neonatal cardiomyocytes was achieved by blocking the CD28/B7 costimulatory pathway via CTLA4-Ig gene transfer. We examined the long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and transient CD40 blockade with anti-CD40L monoclonal antibody (MR1). METHODS AND RESULTS Neonatal cardiomyocytes derived...

The ability to extract somatic cells from a patient and reprogram them to pluripotency opens up new possibilities for personalized medicine. Induced pluripotent stem cells (iPSCs) have been employed to generate beating cardiomyocytes from a patient's skin or blood cells. Here, iPSC methods were used to generate cardiomyocytes starting from the urine of a patient with Duchenne muscular dystrophy...

BackgroundThe clinical outcome of hypertrophic cardiomyopathy patients is not only determined by the disease-causing mutation but influenced a variety disease modifiers. Here, we defined role location and mutant protein dose troponin T mutations I79N, R94C R278C.Methods resultsWe myofilament function after exchange in permeabilized single human cardiomyocytes as well cardiac patient samples har...

This article refers to:Two Co(II) coordination polymers: treatment activity on myocardial injury during sepsis via reducing ROS accumulation in the cardiomyocytes

The heart is one of the most important organs in mammals. When cardiovascular disease occurs, such as myocardial infarction, many cardiac myocytes die due to hypoxia, leading failure. ability adult mammalian cardiomyocytes proliferate gradually decreases during development. Therefore, when damaged, it cannot be repaired by natural division and regeneration cardiomyocytes, which turn leads impai...

BACKGROUND Advanced glycation end-products (AGEs) have been implicated in diverse pathological settings including diabetes, inflammation and acute ischemia/reperfusion injury in the heart. AGEs interact with the receptor for AGEs (RAGE) and transduce signals through activation of MAPKs and proapoptotic pathways. In the current study, adult cardiomyocytes were studied in an in vitro ischemia/rep...

During the development of mammalian heart, left and right atria play an important role in cardiovascular circulation. The embryonic atrium is mainly formed by differentiation progenitor cells proliferation cardiomyocytes, while postnatal primarily shaped increase volume cardiomyocytes. Cell atrial basis for its functions such as “blood reservoir” “supplementary pump”. Deep understanding cellula...

N-n-butyl haloperidol iodide (F2) has been shown to antagonize myocardial ischemia/reperfusion injury by blocking calcium channels. This study explores the biological functions of ERK pathway in cardiomyocytes hypoxia/reoxygenation injury and clarifies the mechanisms by which F2 ameliorates cardiomyocytes hypoxia/reoxygenation injury through the extracellular-calcium-dependent and -independent ...