BACKGROUND Activation of neutrophil adhesion molecules and subsequent neutrophil adhesion to vascular endothelium are key events initiating inflammatory organ dysfunction after cardiopulmonary bypass and ischemic reperfusion. OBJECTIVES We sought to characterize neutrophil integrin CD11b and L-selectin activation associated with coronary artery bypass graft surgery and to determine whether ne...

OBJECTIVE Operations coupled with cardiopulmonary bypass may provoke a systemic inflammatory response, and it has been suggested that this responses causes capillary leakage of proteins, edema formation, and even organ failure. However, capillary leak syndrome is mainly a clinical diagnosis and has not been verified as yet by actual demonstration of protein leakage from the circulation. We have...

is book aims at providing an ‘easily readable source of material for the everyday practice of clinical perfusion’. Th e information included should interest both newcomers to perfusion and also more experienced perfusion ists, anesthesiologists and surgeons. Th is 207-pages work includes 15 chapters, is well illustrated and contains a lot of tables and interesting diagrams. Th e fi rst chapters...

ethods: Male Sprague–Dawley rats were divided into four groups (each n 6): ham group, cardiopulmonary bypass group, and two N-acetylcysteine–treated ardiopulmonary bypass groups (bolus doses of 200 and 500 mg/kg in cardiopulonary bypass prime). Blood samples were collected at the beginning of cardioulmonary bypass, at the cessation of cardiopulmonary bypass, and at 2 and 12 ostoperative hours. ...

Heparin, a polyanionic glycosaminoglycan, is used routinely prior to the induction of cardiopulmonary bypass. Earlier observations in our laboratory suggested that the postoperative bleeding which occurs, despite neutralization of heparin with prdtamine, is secondary to hypothermia and dilutional anemia during bypass. An additional, potential mechanism for excessive bleeding following cardiopul...

BACKGROUND AND PURPOSE High-intensity transient signals (HITS) are the transcranial Doppler representation of both air and solid cerebral emboli. We studied the frequency of HITS associated with different surgical maneuvers during cardiopulmonary bypass for coronary artery bypass graft surgery and their association with postoperative cognitive dysfunction (POCD). METHODS We combined 356 patie...

Cardiopulmonary bypass suppresses circulating thyroid hormone levels. Although acute triiodothyronine repletion has been evaluated in adult patients after cardiopulmonary bypass, triiodothyronine pharmacokinetics and effects have not previously been studied in infants undergoing operations for congenital heart disease. We hypothesized that triiodothyronine deficiency in the developing heart aft...

BACKGROUND Intestinal mucosal ischaemia can occur in infants and children during and after cardiac surgery. Severe decreases in mucosal perfusion may cause complications such as necrotizing enterocolitis and postoperative mortality. We investigated gut permeability in paediatric patients undergoing cardiac surgery using the dual sugar permeability test and absorption of two other saccharides. ...

OBJECTIVES To investigate the effects of the ultrapotent poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhibitor INO-1001 on cardiac and mesenteric function during reperfusion in an experimental model of cardiopulmonary bypass with cardioplegic arrest. DESIGN Prospective, randomized, and blinded experimental study. SETTING Research laboratory. SUBJECTS : Twelve anesthetized dogs...

OBJECTIVES Malignant hyperthermia susceptibility is an important risk factor during general anesthesia. Affected patients have an asymptomatic but potentially lethal hypermetabolic reaction after contact with volatile anesthetics or succinylcholine. Classic symptoms include hemodynamic instability, combined with acidosis, rigor, and hyperthermia. During cardiopulmonary bypass, these signs may b...