Focal chondral lesions of the glenohumeral joint, though less common than chondral defects in the knee or ankle, can be a significant source of pain in an active population. For patients in whom nonsurgical management fails, promising results have been reported after arthroscopic microfracture surgery to treat such lesions. However, microfracture leads to growth of fibrocartilage tissue and is ...

ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upreg...

The cell density and incorporation of 35SO4 and 3H-glycine into human articular cartilage from 8 osteoarthrotic and 7 normal (subcapital fracture) femoral heads were studied. It was found that osteoarthrotic cartilage incorporates on a per cell basis about twice as much 35SO4 and 2--5 times as much 3H-glycine as normal cartilage. There was no relationship between the intensity of incorporation ...

From an anatomical study and clinical review of fractures of the lateral humeral condyle in children, the following conclusions are drawn. The mechanism of injury is a violent varus force with the elbow in extension, the condyle being avulsed by the lateral ligament and the extensor muscles. If the fracture is incomplete, with an intact hinge of pre-osseous cartilage medially, the fragment will...

Open-book fractures of the pelvis are uncommon during childhood and require urgent treatment from the association with other abdominal, vascular or nervous injuries. The case discussed is an open-book fracture (type B1, Tile classification) associated with triradiate cartilage injury (type I, Salter-Harris classification) in an 11-year-old female. Surgical treatment was delayed for 2 months due...

Introduction Oxygen is required for proper tissue healing. Oxygen is an important bacteriocidal agent, is required for the activity of a variety of enzymes, and is required for formation of collagen fibrils (reviewed in: [1]). In addition, oxygen has been proposed to act as a morphogen by regulating differentiation of chondrocytes and osteoblasts in vitro (reviewed in: [2]). Chondrocytes are th...

objective articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. on the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. little is known about the presence of mesenchymal stem cells in articular cartilage tissue. this subject is investigated in the present study. materials and methods articula...

Abstract Despite advanced imaging techniques, more information on the extent of joint degeneration and modifications in tendon collagen content is required for selecting appropriate type shoulder prosthesis. The goal this study was to compare thermal parameters various tissue samples from patients who had arthroplasty correlate shifts with outcomes radiological histopathological assessments. Ro...

Wnt signaling is a key regulator of bone metabolism and fracture healing. The canonical Wnt/β-catenin pathway is regarded as the dominant mechanism, and targeting this pathway has emerged as a promising strategy for the treatment of osteoporosis and poorly healing fractures. In contrast, little is known about the role of non-canonical Wnt signaling in bone. Recently, it was demonstrated that th...

Fractures which unite Nearly 90% of scaphoid fractures unite with conservative treatment2,3 and the overall clinical impression is that patients continue to progress well and remain free of symptoms. However, they are rarely followed up after the fracture has united. Dias, Brenkel and Finlay4 followed up patients for between 1.7 and 2.6 years and found that 20% had some pain and 19% tenderness,...