Subsequent reduction and dearomatizing cyclization reactions open up an entry into the synthesis of novel N-fused polycyclic indolines. The as key step sequence proceeds well with Cu(OTf)2 or TfOH catalyst. At elevated temperature nitro-substituted precursors iron under acidic conditions affords a broad variety indolines directly in two-step cascade reaction good to excellent yields. Using deve...

Abstract A series of tetrazole-linked dibenzo[b,f][1,4]oxazepines is synthesized through a short sequence involving an Ugi tetrazole reaction. The intermediate undergoes potassium carbonate mediated SNAr cyclization, followed by oxidation to afford the target tricyclic heterocyclic scaffold. optimization, scope and limitations this two-step efficient methodology are investigated. 1000-member li...

This study presents a method for the synthesis of thiazinopyrrole fused ring derivatives utilizing ring‐opening recombination strategy with benzothiazole salts. Thiazolium salts, aldehydes, and amines undergo cascade cyclization reaction in one‐pot under solvent conditions ethanol.

We have developed an efficient procedure for the easy and straightforward preparation of functionalized dihydropyridazines as highly enantiopure materials by reaction of pyruvaldehyde 2-tosyl hydrazone with a variety of α,β-unsaturated aldehydes using a chiral secondary amine as catalyst. The overall process consists of a cascade reaction involving an initial aza-Michael reaction, in which the ...

The application of a Pummerer-initiated tandem reaction cascade leads to the highly stereoselective formation of the tetracyclic core of Nakadomarin A.